Clinical trial Recruiting at 1 site Interventional Ages 18 to 50

Thymoquinone 0.2% Gel to Protect Bone After Tooth Extraction

Official title: Clinical and Radiographic Evaluation of the Effect of Thymoquinone 0.2% Gel on Bone Density, Bone Width, and Socket Preservation After Tooth Extraction

Run by Kafrelsheikh University · NCT07765745 · Data updated 2026-11-12

A gel with 0.2% thymoquinone is tested to see if it helps keep bone density and width after pulling a back upper tooth in adults.

Quick facts

Study typeInterventional
Ages18 Years to 50 Years
SexAll
Enrollment30 (estimated)
SponsorKafrelsheikh University
Academic / other
Locations1 site (Kafr ash Shaykh, Kafrelsheikh)
StatusRecruiting
StartedFebruary 1, 2026
Main results expectedFebruary 1, 2027
Study endsFebruary 1, 2027
Registry record updatedAugust 14, 2026
Trial IDNCT07765745 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18–50 requiring extraction of an upper posterior tooth who consent to use of thymoquinone gel and comply with follow-up visits.

Probably not a fit

Patients with intact sockets after extraction or conditions affecting bone healing may not benefit from this intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study tests whether applying a 0.2% thymoquinone gel, with or without gel foam, can preserve the jawbone around an extracted tooth. It looks at changes in bone density, bone width, and socket preservation using clinical and radiographic assessments. The trial targets adults aged 18 to 50 undergoing extraction of upper posterior teeth to see if this gel improves healing and ridge stability.

Why it matters

Potential benefit: If successful, the gel could help maintain jawbone structure after extraction, potentially simplifying future implant placement.

How similar studies have gone: Preclinical studies have shown osteogenic and anti-inflammatory effects of thymoquinone, but clinical efficacy for alveolar ridge preservation remains to be proven.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age: 18-50 years.
* Both sexes.
* Patients requiring extraction of upper posterior teeth will be recruited.

Exclusion Criteria:

* Healthy subjects with intact sockets after extraction.
* Normal mouth opening and good oral hygiene.
* No systemic conditions affecting bone healing.

Where it's running

  • Kafrelsheikh University
    Kafr ash Shaykh, Kafrelsheikh, Egypt
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.