Cryotherapeutic and Nanotherapeutic Sodium Hypochlorite for Post-Operative Endodontic Pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized study, 45 adults with symptomatic irreversible pulpitis and symptomatic apical periodontitis affecting single-rooted mandibular premolars are assigned to three final irrigation methods: conventional room-temperature sodium hypochlorite, cryotheraputic sodium hypochlorite at 2–5°C, and nanotherapeutic sodium hypochlorite with chitosan nanoparticles. Postoperative pain is measured on a 0–10 scale at 12, 24, and 48 hours, and substance P levels are quantified in periapical fluid by ELISA to explore biological correlates of pain. The trial uses a standardized endodontic protocol across groups and compares clinical and biochemical outcomes to see if temperature or nanotechnology modulates pain.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male and female participants aged 18-50 years.
* Participants willing to complete the entire study period and provide written informed consent after receiving a full explanation of the study.
* Presence of a mandibular single-rooted premolar tooth with vital pulp.
* Patients diagnosed with symptomatic irreversible pulpitis and symptomatic apical periodontitis, presenting with intermittent or continuous sharp pain persisting after removal of the stimulus and severe preoperative pain assessed using the Visual Analog Scale (VAS).

Exclusion Criteria:

* Vulnerable populations, including prisoners, pregnant women, and individuals with mental illness, as specified in the protocol.
* Teeth with open apices.
* Teeth previously treated endodontically.
* Presence of sinus tracts.
* Periodontal pockets greater than 3 mm associated with the affected tooth.

Where it's running

• Faculty of dentistry, October 6 university
  Giza, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.