Bioceramic vs Calcium Hydroxide in Root Canal Medicaments for Symptomatic Apical Periodontitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with symptomatic apical periodontitis in permanent mandibular molars are randomized to receive either calcium hydroxide or a bioceramic intracanal medicament after standardized endodontic treatment. Postoperative pain will be recorded using a visual analog scale at multiple time points, and Substance P levels will be measured as a biomarker of pain and inflammation. The study aims to compare pain outcomes and biochemical markers between the two materials to inform clinical decision-making in endodontic therapy. A total of 28 participants are planned, with 14 in each group, under the supervision of Future University in Egypt.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* \- Patients aged 18-45 years with no sex predilection
* Medically free Patients with no systemic conditions that can affect post operative pain response.
* Patients should not be taking any pain medications 24 hours before intervention
* Positive patients' acceptance for participating in the study
* Patient able to sign informed consent
* Permanent mandibular molars diagnosis with Symptomatic Apical Periodontitis
* Permanent molars without any anatomical variations or severe curvatures

Exclusion Criteria:

* \- Medically compromised patients
* Patients who have received antibiotic therapy within the last 2 weeks.
* Pregnant or lactating women.
* Patients with known allergy to any of the irrigants used.
* Patients with swelling or acute peri-apical abscess or fistulous tract.
* Teeth that have:
* Wide or open apex .
* Vital pulp tissue .
* Periodontally affected with grade 2or 3 mobility.
* Non restorable teeth .
* Abnormal anatomy and calcified canals .
* Pervious root canal treatment.
* severe curved canal
* Buccolingual and mesiodistal radiographs were taken to evaluate the root canal anatomy

Where it's running

• Future University in Egypt - Faculty of Oral and Dental Medicine
  Cairo, Egypt Recruiting

Study contacts

• Principal investigator: Adel Abdelwahed, Prof. Ass. of endodontic — Prof. Ass. of endodontic, faculty of Oral and Dental Medicine Future University in Egypt
• Study coordinator: Salma Tarek Abdullah, Bachelors degree
• Email: salma1319142066@gmail.com
• Phone: +201060044225

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.