Local dexamethasone to improve anesthesia in painful irreversible pulpitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, single-blind study compares three approaches to dexamethasone administration alongside a standard inferior alveolar nerve block in adults with symptomatic irreversible pulpitis of mandibular first or second molars. Participants are assigned to: placebo submucosal injection, submucosal dexamethasone, or intraligamentary dexamethasone, with the primary outcome being anesthetic success during access and pulp removal measured by HP-VAS. Secondary outcomes include postoperative pain and other tolerability measures. The trial aims to determine if local dexamethasone can improve anesthesia success and pain control without adding undue risk. Enrollment targets 84 participants across Marmara University Faculty of Dentistry in Istanbul.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 18 to 65 years.
* ASA I or ASA II systemic health status.
* Symptomatic irreversible pulpitis in a mandibular molar tooth.
* Positive response to pulp sensibility tests.
* Preoperative pain score greater than 54 mm on the Heft-Parker Visual Analog Scale (HP-VAS).
* Ability to understand the study procedures and provide written informed consent.

Exclusion Criteria:

* Pregnancy or lactation.
* Allergy or contraindication to articaine, dexamethasone, or study-related medications.
* Use of analgesics, anti-inflammatory drugs, or antibiotics within the previous 12 hours.
* Presence of periapical radiolucency or diagnosis of pulpal necrosis.
* Significant systemic disease (ASA III or higher).
* Inability to complete pain assessment forms or follow study procedures.

Where it's running

• Marmara University Faculty of Dentistry
  Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: Elif İrem Altıntaş, Research Assistant
• Email: eialtintas@icloud.com
• Phone: +905425491411

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.