Postoperative Pain After Double Antibiotic Paste vs Calcium Hydroxide in Symptomatic Apical Periodontitis
Official title: Comparison of Mean Postoperative Pain After Using Double Antibiotic Paste Versus Calcium Hydroxide as an Intracanal Medicament in Teeth With Symptomatic Apical Periodontitis: A Randomized Controlled Trial
Run by College of Physicians and Surgeons Pakistan · NCT07867951 · Data updated 2026-11-12
This trial tests whether double antibiotic paste or calcium hydroxide leads to less pain after treatment in a single-tooth infection around the tooth root.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 16 Years to 50 Years |
| Sex | All |
| Enrollment | 662 (estimated) |
| Sponsor | College of Physicians and Surgeons Pakistan Academic / other |
| Locations | 1 site (Swāt, Kpk) |
| Status | Recruiting |
| Started | September 5, 2025 |
| Main results expected | May 5, 2026 |
| Study ends | October 5, 2026 |
| Registry record updated | October 9, 2026 |
| Trial ID | NCT07867951 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are 16–50 years old with a single tooth diagnosed with symptomatic apical periodontitis and good general health.
✕Probably not a fit
Patients with multiple treated teeth, pregnancy, recent antibiotic use, or conditions preventing rubber dam isolation may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial compares two intracanal medicaments, double antibiotic paste and calcium hydroxide, in teeth with symptomatic apical periodontitis. Participants aged 16 to 50 with a single affected tooth are randomly assigned to receive one of the medicaments after standard root canal preparation. Postoperative pain is measured using a 10-point visual analog scale at 1 hour and 24 hours after treatment. The study aims to determine which medicament better reduces early postoperative pain. Outcomes will inform pain management strategies in endodontic therapy.
Why it matters
Potential benefit: If effective, one medicament could reduce patient discomfort after root canal treatment.
How similar studies have gone: Similar approaches using intracanal medicaments have shown differences in outcomes, but direct head-to-head pain comparisons are limited, making this investigation novel for pain outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria:1. Patients with ages ranging from 16 to 50 years. 2. Teeth diagnosed with symptomatic apical periodontitis clinically by percussion and radiographically by the presence of radiolucency around the tooth apex. 3\. Patients with good general health (no medical condition). \- Exclusion Criteria: * 1\. Pregnant women. 2. Patients who had received antibiotic treatment during the last 3 months. 3. Patients having more than one tooth requiring root canal treatment. 4. Teeth with periodontal probing depth \>4 mm measured with W.H.O probe. 5. Teeth that couldn't be isolated with a rubber dam. 6. Teeth with previous root canal treatment, or teeth with fluctuant facial swelling where emergency management should include incision and drainage.
Where it's running
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Saidu College of dentistry,Swat
Swāt, Kpk, Pakistan Recruiting
Study contacts
- Study coordinator: Jamal Ahad
- Email: jamalkha230@gmail.com
- Phone: 03329475002
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Cryotherapeutic and Nanotherapeutic Sodium Hypochlorite for Post-Operative Endodontic Pain
This trial tests whether cooling or nano-enhanced sodium hypochlorite as the final root canal irrigant can reduce pain after treatment in adults with certain tooth infections.
-
Bioceramic vs Calcium Hydroxide in Root Canal Medicaments for Symptomatic Apical Periodontitis
This study tests whether a bioceramic intracanal medicament reduces postoperative pain compared with calcium hydroxide in adults with symptomatic apical periodontitis.
-
Using melatonin to help treat childhood pneumonia
This study is testing if adding melatonin to the usual antibiotic treatment can help children with pneumonia leave the hospital sooner.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.