Pain relief after a single-visit root canal: comparing acetaminophen, NSAIDs, and trypsin-chymotrypsin combo
Official title: Comparing the Effect of Acetaminophen, NSAIDs, Trypsin-chymotrypsin + Acetaminophen on Post-endodontic Pain Using Visual Analog Scale (VAS) After Single Visit Endodontic Treatment: A Randomized Controlled Trial
Run by Dow University of Health Sciences · NCT07759349 · Data updated 2026-11-12
This trial tests whether acetaminophen alone, an NSAID, or a combination of trypsin-chymotrypsin with acetaminophen best relieves pain after a single-visit root canal in adults with symptomatic irreversible pulpitis.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | Dow University of Health Sciences Academic / other |
| Locations | 1 site (Karachi, Sindh) |
| Status | Recruiting |
| Started | August 2, 2026 |
| Main results expected | December 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | August 19, 2026 |
| Trial ID | NCT07759349 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–60 with symptomatic irreversible pulpitis of a mandibular premolar (single canal) requiring root canal treatment and ASA I health status.
✕Probably not a fit
Patients with non-vital teeth, multiple canals, peri-radicular pathology, or contraindications to the study medications may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This early-phase, single-center, randomized trial uses a parallel-arm design with 1:1 allocation to three treatment groups. Participants with symptomatic irreversible pulpitis undergoing single-visit root canal treatment will be randomized after screening and consent. Pain will be measured with a standardized pain scale to compare the three regimens. The study follows PRIRATE 2020 guidelines for reporting endodontic trials and is conducted at Dow University of Health Sciences in Karachi. Safety monitoring and eligibility criteria are applied to ensure participants are ASA I adults 18–60 without excluded conditions.
Why it matters
Potential benefit: If successful, the preferred pain management approach after root canal treatment could improve patient comfort and reduce reliance on analgesics.
How similar studies have gone: Previous endodontic pain trials have explored analgesic combinations; this trial tests a novel combination with trypsin-chymotrypsin added to acetaminophen.
Who can join: the full rules
Show full inclusion / exclusion criteria
INCLUSION CRITERIA * Both sex * Healthy ( American Society of Anesthesiologists class 1) * Age 18-60 years * Pulpal diagnosis: Symptomatic irreversible pulpitis in mandibular premolar (single canal) periapical diagnosis: symptomatic apical periodontitis * The ability of participants to understand a pain scale (VAS) Exclusion Criteria: * Pregnant females * Systemic disease and immune deficiency * Taken analgesics 24 hours, prior to treatment * Non-vital, previously initiated, previously treated teeth * Radiographic evidence of peri-radicular pathosis * Teeth with cracks, fractures and history of trauma * Developmental anomalies and immature apices * Allergic to local anesthetic solution or any experimental drugs * Patient being unable to provide informed consent.
Where it's running
-
Dow University of Health Sciences
Karachi, Sindh, Pakistan Recruiting
Study contacts
- Study coordinator: Dr. Kanchan Devi Dr. Kanchan Devi, Bachelor In Dental Surgery
- Email: kanchanharmit@gmail.com
- Phone: 092333-2972137
Similar studies
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This trial will see if an intraligamentary injection or an inferior alveolar nerve block gives better pain control for adults having root canal treatment of a painful lower molar with symptomatic irreversible pulpitis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.