Postoperative pain after root canal filling with bioceramic versus calcium hydroxide sealers.
Official title: Assessment of Postoperative Pain in Patients Obturated With Bioceramic and Calcium Hydroxide Sealers: A Randomized Clinical Trial
Run by HITEC-Institute of Medical Sciences · NCT07410780 · Data updated 2026-11-12
We are testing whether using a bioceramic or a calcium hydroxide root canal sealer leads to less pain after root canal treatment in people with symptomatic irreversible pulpitis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 40 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | HITEC-Institute of Medical Sciences Academic / other |
| Locations | 1 site (Rawalpindi, Punjab Province) |
| Status | Recruiting |
| Started | January 1, 2026 |
| Main results expected | December 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | February 17, 2026 |
| Trial ID | NCT07410780 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–40 with a single-rooted, restorable permanent tooth diagnosed with symptomatic irreversible pulpitis and normal periapical radiographs (or only PDL widening) are ideal candidates.
✕Probably not a fit
Patients with necrotic pulp, immature roots, root resorption, calcified canals, systemic conditions affecting treatment, multi-rooted teeth, or those outside the 18–40 age range are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, single-blind clinical trial will enroll 50 adults with symptomatic irreversible pulpitis and randomly assign them to receive either a bioceramic (calcium silicate-based) sealer or a calcium hydroxide-based sealer during single-visit root canal treatment. All procedures will be performed by the same operator under local anesthesia and rubber dam isolation, with standardized canal preparation and irrigation. Participants will report postoperative pain levels for several days after the procedure to compare early discomfort between the two sealers. The trial is conducted at the Department of Operative Dentistry, HITEC-IMS Dental College in Rawalpindi.
Why it matters
Potential benefit: If successful, the results could help dentists choose a sealer that reduces short-term pain and improves comfort after root canal treatment.
How similar studies have gone: Previous clinical and laboratory studies comparing bioceramic and calcium hydroxide-based sealers have produced mixed but generally promising results, with some trials reporting reduced postoperative pain using bioceramic sealers.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18-40 years * Single-rooted permanent teeth * Teeth diagnosed with symptomatic irreversible pulpitis * Normal periapical condition on radiographic examination or periodontal ligament (PDL) space widening * Restorable teeth Exclusion Criteria: * Patients with systemic conditions that could alter the course of treatment * Teeth with immature root development * Teeth with necrotic pulp * Teeth exhibiting root resorption * Teeth with calcified root canals
Where it's running
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Department of Operative Dentistry, HITEC-IMS Dental College
Rawalpindi, Punjab Province, Pakistan Recruiting
Study contacts
- Principal investigator: Monal Fatima — HITEC-IMS, Department of Operative Dentistry, Taxila, Pakistan
- Study coordinator: Monal Fatima, BDS
- Email: manalfatima1100@gmail.com
- Phone: 03004410676
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Cryotherapeutic and Nanotherapeutic Sodium Hypochlorite for Post-Operative Endodontic Pain
This trial tests whether cooling or nano-enhanced sodium hypochlorite as the final root canal irrigant can reduce pain after treatment in adults with certain tooth infections.
-
Pain relief after a single-visit root canal: comparing acetaminophen, NSAIDs, and trypsin-chymotrypsin combo
This trial tests whether acetaminophen alone, an NSAID, or a combination of trypsin-chymotrypsin with acetaminophen best relieves pain after a single-visit root canal in adults with symptomatic irreversible pulpitis.
-
Partial pulpotomy in mature lower molars with SIP using calcium hypochlorite vs sodium hypochlorite
This trial tests whether washing the exposed pulp with calcium hypochlorite or with sodium hypochlorite during partial pulpotomy in adults helps healing and reduces pain.
-
Local dexamethasone to improve anesthesia in painful irreversible pulpitis
This trial tests whether giving dexamethasone under the gum or between tooth-supporting ligaments helps make anesthetic blocks work better and reduce pain in adults with painful irreversible pulpitis in the lower molars.
-
Using intraoral cold to improve numbness in lower front teeth
This trial will see if applying cold inside the mouth helps buccal infiltration anesthesia work better for adults with symptomatic irreversible pulpitis in a lower front tooth.
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Comparing MTA versus Biodentine for complete pulpotomy in painful molars
This will test whether MTA or Biodentine works better to relieve pain and preserve the tooth in adults (18–40) with symptomatic irreversible pulpitis in a molar.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.