Assessing immune responses after acute ischemic stroke treatment
Official title: IMMunological resPonse Assessment afteR Acute iSchemic Stroke Treated With Endovascular Therapy
Run by Fondation Ophtalmologique Adolphe de Rothschild · NCT04663399 · Data updated 2026-11-12
This study is testing how the immune system reacts in patients treated for an acute ischemic stroke to see if these responses can help predict their recovery after three months.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1200 (estimated) |
| Sponsor | Fondation Ophtalmologique Adolphe de Rothschild Research network |
| Drugs / interventions | Natalizumab |
| Locations | 1 site (Paris, Paris) |
| Status | Recruiting |
| Started | February 23, 2023 |
| Main results expected | May 23, 2028 |
| Study ends | May 23, 2028 |
| Registry record updated | January 23, 2026 |
| Trial ID | NCT04663399 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients experiencing an acute ischemic stroke who are eligible for mechanical thrombectomy.
✕Probably not a fit
Patients who are pregnant, breastfeeding, or under legal protection measures may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The IMPRESS study aims to evaluate the immuno-inflammatory and thrombo-inflammatory profiles of patients undergoing treatment for acute ischemic stroke with mechanical thrombectomy. It focuses on the first 24 to 36 hours post-treatment to understand how these immune responses may influence functional outcomes at three months. By identifying reliable biomarkers, the study seeks to enhance the understanding of stroke recovery and potentially guide future therapeutic interventions. This observational study will include patients who meet specific criteria related to their stroke treatment.
Why it matters
Potential benefit: If successful, this study could lead to improved prognostic assessments and targeted therapies for patients recovering from acute ischemic stroke.
How similar studies have gone: While many preclinical studies have shown promise in understanding immune responses in stroke, this specific approach in humans is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient with an acute ischemic stroke for which treatment with mechanical thrombectomy is indicated, whether or not thrombectomy is performed, * Having received informed information about the study and having signed a consent to participate in the study (if this is not possible: information and consent of the trusted support person or family member if present; emergency inclusion if absent); * Affiliated or beneficiary of a social security scheme or equivalent. Non inclusion Criteria: * Pregnant or breast-feeding women * Patient benefiting from a legal protection measure Exclusion Criteria: None.
Where it's running
-
Hôpital Fondation Adolphe de Rothschild
Paris, Paris, France Recruiting
Study contacts
- Principal investigator: Benjamin Maier, MD — Fondation Ophtalmologique Adolphe de Rothschild
- Study coordinator: Benjamin Maier, MD
- Email: bmaier@for.paris
- Phone: 0148036556
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Michigan experience using the Tigertriever device to remove brain clots
This project tries to see if the Tigertriever device safely and effectively removes large brain clots in adults who have an ischemic stroke within 8 hours of symptom onset.
-
Anesthesia choice for mechanical thrombectomy in ischemic stroke
In people with severe ischemic stroke due to a large vessel blockage who need mechanical thrombectomy, this study tests whether general anesthesia works better than procedural sedation for improving daily function 3 months later.
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AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals
This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.
-
Remote ischemic conditioning for post-stroke insomnia
A 136-person, randomized study will test whether a non-invasive arm-cuff procedure done twice daily for 90 days can improve sleep after a first ischemic stroke in adults 18–80.
-
Ear-based nerve stimulation to help sleep after a stroke
A device that delivers vagal nerve stimulation through the ear is tested to see if it helps stroke patients in rehab sleep better.
-
Theta Burst Stimulation to Help Stroke Recovery (Upper and Lower Limbs)
This trial tests whether applying theta burst stimulation to the motor cortex, in combination with standard rehabilitation, helps people over 45 who recently had a first ischemic stroke recover arm and leg movement.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.