Sponsor or institution
Clinical trials and research at University of Texas Hlth Science Center
As of November 12, 2026, Find a Trial lists 503 NIH-funded research projects at this institution, with $316.7 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 503NIH research projects
NIH-funded research (newest 40 of 503)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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LRP1 controls NSC movement and stroke recovery
This NIH grant studies how a brain receptor called LRP1 helps neural stem cells move to stroke injuries and support recovery in adults.
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Rural microvascular factors driving brain aging and dementia
This project will study how blood vessel problems in rural communities contribute to brain aging and dementia, using mobile clinics to reach people who live far from major medical centers.
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How COVID-19 infection and genes may influence memory and dementia risk
This study looks at how getting COVID-19 and a person’s genes together affect the chance of developing memory problems and Alzheimer’s disease later in life.
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Gene editing therapies to prevent epileptic seizures
A new gene-editing approach aims to reduce seizures in people with epilepsy by directly modifying a brain gene tied to the condition.
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Blocking the IL-4/13 pathway in allergic asthma and rhinoconjunctivitis to understand why treatments work differently
A high-quality clinical trial will test a targeted therapy in people with allergic asthma and allergic rhinitis to understand why symptoms and responses vary.
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Hormonal Influences on Inflammation in Endometriosis
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
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Texas Pediatric cancer care network expands access to trials
A Texas-wide network helps children, teens, and young adults with cancer access cutting-edge clinical trials closer to home.
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Testing new therapies for pediatric and young adult sarcoma, kidney, and liver cancers
Researchers are testing new drugs and smart combinations in models of pediatric cancers to help guide future treatments for kids and young adults.
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Sleep and dementia: a large resource to study how sleep problems relate to Alzheimer’s and related dementias
A large project uses brain sleep data and health records to understand how poor sleep may influence the development of Alzheimer’s and related dementias.
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New compounds that block pain-sensing nerves without blocking other senses or movement
Researchers are creating a high-throughput test to find substances that specifically quiet pain-sensing nerves (nociceptors) with the goal of safer, peripheral-only pain relief.
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DSPP signaling and dentin formation in teeth
A study exploring how specific signals control dentin formation to help repair and regenerate tooth tissue.
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Mexican Health and Aging: tracking memory and health in older adults
Following adults 50 and older across Mexico over time to learn how aging, memory, and dementia change and affect people’s lives.
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Improving dementia research and care in French-speaking sub‑Saharan Africa
This project will build local teams, tools, and networks to better understand Alzheimer’s and related dementias for older adults and their families in French‑speaking parts of sub‑Saharan Africa.
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How cells choose and fix broken DNA ends
This project looks at how cells repair dangerous double-strand DNA breaks to help improve treatment responses in people with BRCA-related cancers.
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Why some people stay mentally sharp into their 90s
This project brings together many long-running studies to find what helps people stay mentally healthy past age 85 and why dementia often appears so late in life.
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Why some people stay mentally sharp into their 90s
Bringing together long-term health data to find what helps people remain cognitively healthy past age 85.
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Why some people stay mentally sharp into their 90s
Combining long-term health data from many older adults to find what helps people stay mentally sharp into their 90s.
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Staying mentally sharp into your 90s
This project combines long-term health information to learn why some people stay mentally sharp past age 90 while others develop dementia.
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How genes influence endometriosis in women of different racial and ethnic backgrounds
The team will compare genetic changes in tissue from women of various races who have endometriosis to find molecular targets for better treatments.
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How the brain rewires after stroke: a new look at restoring movement
This project tests a new imaging and analysis approach in adults to understand how stroke changes brain connections and whether these changes can be guided to improve movement.
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Aortic stiffness and brain health: how arterial pulses affect dementia risk
This project looks at whether stiffer arteries and pulsing blood flow are linked to brain small vessel damage and changes in thinking in middle-aged adults.
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Targeting MAGL in brain support cells to help people with Alzheimer’s
This project aims to lower MAGL activity in brain support cells (astrocytes) to reduce inflammation and protect memory in people with Alzheimer's disease.
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Peer Recovery Innovation Network: Building collaboration to boost opioid recovery supports
A nationwide effort to strengthen and expand peer-based recovery support services for people with opioid use disorder by connecting researchers, community organizations, and care providers.
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Targeting Aging Pathways in Alcohol-Related Liver Disease
This grant explores how aging-related cellular changes contribute to alcohol-related liver disease and tests potential therapies.
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Targeting ERBB3-positive cancer cells to treat childhood rhabdomyosarcoma
Aimed at treating children with a tough form of muscle cancer by focusing on a specific cell type that helps tumors grow and resist therapy.
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Understanding how a specific RNA modification influences uterine fibroids and new ways to treat them
Researchers are studying how a chemical change to RNA called pseudouridylation might cause uterine fibroids and whether new inhibitors could offer non-surgical treatment options.
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Hormonal links to inflammation in endometriosis
A study to understand how hormones influence immune signals in endometriosis to help explain symptoms and identify potential targets for treatment.
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Computational Chemistry, Biophysics & Bioinformatics for Cancer-Related APOBEC Mutation Prevention
Researchers will use computer models to understand and block APOBEC enzymes (A3A and A3B) to reduce mutations in cancer and help treatments last longer.
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Proteins and Assays Core for Cancer Research (APOBEC3 enzymes)
A funded core facility helps scientists study APOBEC3 enzymes that may drive mutations in many cancers by providing proteins, antibodies, and standardized assays.
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Biology of DNA Deaminases in Cancer
A research project to understand how APOBEC3A and APOBEC3B enzymes drive mutations in cancer and how turning off their activity might slow tumor progression.
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Chemical tools to block DNA editing enzymes that drive cancer
Aims to develop chemical inhibitors that block APOBEC3A and APOBEC3B enzymes, which can cause mutations in cancer and help tumors become resistant to therapy.
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Structural biology of DNA deaminases in cancer
This grant aims to understand how specific enzymes called APOBEC3A and APOBEC3B drive cancer by mutating DNA, with the goal of finding ways to block these mutations to slow tumor evolution.
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Administrative Core for Coordinated Breast Cancer Program
A central administrative grant supports leaders, teams, and collaborators to move breast cancer research forward and keep programs well-organized and on track.
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APOBEC Mutagenesis in Cancer
A team at a major health center is exploring how APOBEC enzymes drive mutations in bladder and other cancers and testing ways to block this process to slow cancer progression.
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Behavioral steps to cut HIV risk using timing-based thinking
A young adult-focused program tests a behavioral tool to help 18–34 year olds stick with HIV prevention and reduce risky behaviors.
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Comunidad: Expanding Long COVID care in underserved South Texas
A new program will broaden and coordinate Long COVID care for underserved communities in San Antonio and South Texas to improve access and outcomes.
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Glucagon's diabetes-related effects after bariatric surgery
This project looks at how glucagon affects blood sugar in adults with type 2 diabetes, comparing people who have had bariatric surgery to those who haven’t.
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Bringing Alzheimer's blood biomarkers to a broad population
A physician-scientist team is testing blood tests for Alzheimer’s-related signals in diverse adults to see how well they work in real-world settings.
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PositiveLinks for Youth in Texas: A mobile health tool to help young adults with HIV stay in care
A mobile health program called PL4Y helps young adults with HIV in Texas stay engaged with care and improve viral suppression.
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Targeting key helper T cells in lupus
A study that looks at how certain immune cells that help B cells produce harmful antibodies contribute to lupus, aiming to find ways to interrupt this process.
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