Glucagon's diabetes-related effects after bariatric surgery
Official title: Glucagon-mediated glycemic effect in humans with and without rerouted gut after bariatric surgery
Funded at University of Texas Hlth Science Center · NIH-11413804 · Data updated 2026-11-12
This project looks at how glucagon affects blood sugar in adults with type 2 diabetes, comparing people who have had bariatric surgery to those who haven’t.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 10, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $781,758 |
| NIH project number | 5R01DK141843-02 |
| Project ID | NIH-11413804 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with type 2 diabetes who have undergone gastric bypass or sleeve gastrectomy, as well as non-operated adults with diabetes or obesity for comparison.
✕Less likely to help
Individuals without diabetes or those not considering bariatric surgery are unlikely to directly benefit from this study.
What this research studies
In people with or without bariatric surgery, researchers will examine how glucagon acts in the liver to influence glucose levels during different states of feeding and fasting. The study builds on prior findings that weight-loss surgeries change glucose responses and glucagon dynamics, and will test how hepatic glucagon actions differ after gastric bypass or sleeve gastrectomy versus non-operated controls. By using physiological conditions, the team aims to clarify why some patients experience hypoglycemia after surgery and whether glucagon contributes differently to glucose regulation in these groups. The results could inform safer diabetes management and personalized treatment after bariatric procedures.
Why it matters
Potential benefit: If successful, the research could improve understanding of post-surgery glucose control and lead to better strategies to prevent hypoglycemia in bariatric patients with diabetes.
How similar studies have gone: Previous work has shown altered glucagon and glucose dynamics after bariatric surgery, suggesting the study could extend these findings in a more comprehensive physiological context.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Salehi, Marzieh — University of Texas Hlth Science Center
- Study coordinator: Salehi, Marzieh
Related research
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Gut bacteria changes after bariatric surgery and colorectal cancer risk
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.