LRP1 controls NSC movement and stroke recovery
Official title: LRP1 as a novel regulator of CXCR4 in adult neural stem cells and post-stroke response
Funded at University of Texas Hlth Science Center · NIH-11617802 · Data updated 2026-11-12
This NIH grant studies how a brain receptor called LRP1 helps neural stem cells move to stroke injuries and support recovery in adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | August 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $29,838 |
| NIH project number | 3R01NS132778-04S1 |
| Project ID | NIH-11617802 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with acquired brain injury due to ischemic stroke who might benefit from future stem cell–related therapies.
✕Less likely to help
Patients with non-stroke brain injuries or without potential future stem cell therapies may not benefit from this research.
What this research studies
After an ischemic stroke, survivors often face lasting disabilities. This project looks at neural stem cells in adult brains and how they respond to signals after a stroke. The researchers found that removing LRP1 from these cells changes how they migrate to injury sites and affects lesion size and function, and that LRP1 loss also reduces CXCR4, a receptor important for guiding cells to damaged areas. By understanding this pathway, the work aims to improve how stem cells could be used to aid recovery in stroke patients. The study will use mouse models to reveal mechanisms that could inform future human therapies.
Why it matters
Potential benefit: If successful, this work could guide new strategies to enhance stem cell–based therapies for improving recovery after stroke.
How similar studies have gone: Previous studies have shown that manipulations of neural stem cells can influence stroke outcomes, with this project exploring a novel role for LRP1 and CXCR4.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Sayre, Naomi Ledene — University of Texas Hlth Science Center
- Study coordinator: Sayre, Naomi Ledene
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.