Staying mentally sharp into your 90s
Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · NIH-11470425
This project combines long-term health information to learn why some people stay mentally sharp past age 90 while others develop dementia.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCIENCE CENTER (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-11470425 on ClinicalTrials.gov |
What this research studies
You would be represented by long-term health and cognitive data from people who were followed from middle age into their 80s and 90s. Researchers will combine multiple cohort studies so there are enough people who reached age 90 without dementia to compare with those who developed dementia. They will examine past medical history, genetics (for example APOE), brain markers such as Aβ-42, vascular and lifestyle risks, and other health measures to look for patterns of risk and resilience. The work pools existing clinical records and biological measures rather than testing new treatments.
Who could benefit from this research
Good fit: Ideal participants are older adults (especially people aged 85 or older) who have long-term medical, cognitive, or biological data available or who are enrolled in one of the contributing cohort studies.
Not a fit: People without long-term follow-up data or biological samples, and those seeking immediate treatment options, are unlikely to get direct benefit from this project.
Why it matters
Potential benefit: If successful, this research could reveal factors and biomarkers that help prevent or delay dementia in very old adults.
How similar studies have performed: Previous pooled cohort efforts have successfully identified Alzheimer and vascular risk factors, but focusing on resilience and cognitive health specifically in the nonagenarian population is less commonly studied and relatively novel.
Where this research is happening
SAN ANTONIO, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCIENCE CENTER — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SESHADRI, SUDHA — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- Study coordinator: SESHADRI, SUDHA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury