Biology of DNA Deaminases in Cancer
Official title: PROJECT 3 – BIOLOGY OF DNA DEAMINASES IN CANCER
Funded at University of Texas Hlth Science Center · NIH-11418441 · Data updated 2026-11-12
A research project to understand how APOBEC3A and APOBEC3B enzymes drive mutations in cancer and how turning off their activity might slow tumor progression.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | August 9, 2019 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $317,011 |
| NIH project number | 5P01CA234228-07 |
| Project ID | NIH-11418441 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cancers linked to APOBEC-driven mutagenesis may be eligible for future translational trials arising from this work.
✕Less likely to help
This particular basic research grant does not enroll patients directly and thus does not offer immediate patient participation.
What this research studies
This grant focuses on how the APOBEC3A and APOBEC3B enzymes become dysregulated in tumor cells and contribute to cancer progression. Researchers will study the regulation of these enzymes at the protein level and how different cellular pathways influence the types of mutations observed. They will use human cell systems and novel mouse models to explore how inhibiting A3A/B activity could slow tumor evolution and improve outcomes. The work combines genetics, proteomics, and informatics to map the upstream and downstream factors that shape mutagenesis in cancer.
Why it matters
Potential benefit: If successful, the research could lead to new strategies to slow cancer progression by targeting APOBEC enzymes.
How similar studies have gone: Previous work has implicated A3A and A3B in cancer mutagenesis, with ongoing efforts to translate this into targeted therapies.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Harris, Reuben S — University of Texas Hlth Science Center
- Study coordinator: Harris, Reuben S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.