Understanding how a specific RNA modification influences uterine fibroids and new ways to treat them
Official title: Decoding the pseudouridine epitranscriptome in uterine fibroids.
Funded at University of Texas Hlth Science Center · NIH-11431795 · Data updated 2026-11-12
Researchers are studying how a chemical change to RNA called pseudouridylation might cause uterine fibroids and whether new inhibitors could offer non-surgical treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $699,359 |
| NIH project number | 1R01HD124930-01 |
| Project ID | NIH-11431795 on NIH RePORTER |
Who could benefit from this research
✓Could help
Women with uterine fibroids or those at risk who would benefit from non-surgical treatment options.
✕Less likely to help
Women without uterine fibroids or those unlikely to respond to RNA-targeted therapies may not benefit.
What this research studies
This project looks at how RNA modifications like pseudouridine might drive the growth of uterine fibroids and tests potential drugs that could block these changes. Using human uterine tissue samples and cellular models, the team will map where pseudouridine changes occur and which enzymes control them. If successful, this could point to non-invasive therapies that target the root causes in the fibroid cells.
Why it matters
Potential benefit: If successful, the study could lead to non-invasive treatments that reduce fibroid growth and improve quality of life for patients.
How similar studies have gone: Other studies have linked RNA modifications to disease processes, but this approach in fibroids is still exploratory.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Boyer, Thomas G — University of Texas Hlth Science Center
- Study coordinator: Boyer, Thomas G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.