Sponsor or institution
Clinical trials and research at University of Oklahoma Hlth Sciences Ctr
As of November 12, 2026, Find a Trial lists 343 NIH-funded research projects at this institution, with $182.6 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 343NIH research projects
NIH-funded research (newest 40 of 343)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Primary care research network in Oklahoma to boost rural patient trials
A nationwide NIH-supported effort to strengthen Oklahoma’s primary care research network so doctors can run big clinical trials and real‑world studies in rural communities.
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N-myristoylation and DNA damage response in Alzheimer’s disease
A study to understand how a protein modification called myristoylation affects the DNA damage response in people who have Alzheimer’s-related conditions.
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Genetically engineered mouse model to study and treat high-risk pediatric rhabdomyosarcoma
A research project aims to create mouse models that mimic high-risk pediatric rhabdomyosarcoma and test therapies that target the NOTCH1 pathway to slow or stop tumor growth.
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Understanding how bone cancer cells rely on certain pathways to grow in childhood osteosarcoma
This grant studies how specific cancer-related pathways in bone-forming cells drive osteosarcoma in children, with the aim of finding better treatments.
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Vascular signals from brain blood vessels influence immune-suppressing cells in glioblastoma
This grant explores how blood vessel cells in glioblastoma shape immune cells to help the tumor grow, with the aim of making immunotherapies work better for patients.
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TFEB as a key switch to keep muscles healthy as we age
A study in aging adults and aging muscle tissues looks at whether boosting TFEB can improve how muscles maintain themselves and recover after disuse.
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I-STOP: a mobile health program to help people with HIV quit smoking
A smartphone-based program designed to help people with HIV quit smoking in a sustainable, affordable way.
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Parathyroid hormone helping bone cells use marrow fat
This project looks at whether intermittent parathyroid hormone helps bone cells use fat in the marrow to build stronger bones for people with osteoporosis or low bone density.
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How the brain links metabolism and sleep-wake cycles
Researchers are looking at how the hormone leptin and specific hypothalamus brain cells control sleep and wakefulness to help people with obesity-related sleep problems.
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Role of MPST and mitochondria in oxygen-related neonatal airway disease
A study in newborn airways looks at how a mitochondrial enzyme called MPST affects breathing problems in preterm babies exposed to high oxygen levels.
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IL-22’s role in SARS-CoV-2 infection and tissue protection
A short study to understand how the cytokine IL-22 might help protect tissues during and after COVID-19 infection, especially in people with complications related to acute graft-versus-host disease.
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Understanding cervical spinal cord compression in people with and without myelopathy
Researchers are studying how spinal cord compression in the neck affects people, including those with mild or no symptoms, to find better imaging tools and early signs of trouble.
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Targeting hormone resistance to prevent endometrial cancer
Aims to boost progesterone’s cancer-preventing effect in the lining of the uterus to stop cancer from developing in people at risk, especially those who are obese or young.
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SPIRIT: Culturally grounded supportive care for Chickasaw Nation cancer patients
A culturally tuned supportive care program called SPIRIT is being developed and piloted to help Chickasaw Nation cancer patients receive more coordinated and respectful care.
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High-fat diet and immune cell changes in pancreatic cancer
This project studies how a lard-based high-fat diet changes the immune system and tumor growth in a mouse model of pancreatic cancer to understand obesity-related effects on the disease.
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Tailored mobile pain solution for Native American communities
A new mobile health program will help Native American adults manage chronic pain using strategies that fit their culture, daily life, and smartphone use.
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Mechanisms of cisplatin resistance from secondhand smoke in head and neck cancer
This project looks at why secondhand smoke makes chemotherapy less effective for people with head and neck cancer, focusing on cisplatin resistance.
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Alpha-Ketoglutarate and brain blood flow to support memory in older adults
A study in older adults will test whether a natural compound called alpha-ketoglutarate can improve brain blood flow and memory performance.
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ZC3H15 in pancreatic cancer growth and treatment response
A study exploring how the protein ZC3H15 affects the progression of pancreatic cancer and how it responds to therapies, with the goal of helping patients with this very deadly cancer.
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A new approach to help adults who aren’t ready to quit start quitting more often
A health intervention uses tailored daily messages to motivate and support adults who aren’t ready to quit smoking, helping them make quit attempts and stay abstinent.
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Comprehensive child sexual abuse prevention in rural elementary schools
A large classroom- and school-wide program in rural elementary schools tests how a multi-layered approach can reduce child sexual abuse and harmful youth sexual behavior.
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Targeting MARK2-HDAC signaling to overcome paclitaxel resistance in pancreatic cancer
A patient-centered approach aims to make paclitaxel work better for pancreatic cancer by blocking a specific cell signaling pathway.
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MUC1 and Therapy Resistance in Pancreatic Cancer
A patient-facing overview of how high MUC1 levels may make pancreatic cancer harder to treat and what the research hopes to learn.
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Understanding how pancreatic cancer stops responding to chemotherapy and how to overcome it
This project looks at why pancreatic cancer often stops responding to chemotherapy and tests new ideas to overcome that resistance in patients with this disease.
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Cancer Metabolism Core for Pancreatic Cancer Research and Therapy Resistance
A centralized core lab helps study how metabolism and signaling changes drive therapy resistance in pancreatic cancer, supporting multiple projects.
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Tissue Core for Rapid Autopsy and Pancreatic Cancer Biorepository
A centralized tissue and biofluid biorepository program collects and distributes deidentified human samples from pancreatic cancer patients and deceased donors to study how the cancer becomes resistant to treatment.
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Administrative Core for Pancreatic Cancer ARTNet Center
This grant supports the Administrative Core that coordinates and guides a national network focused on pancreatic cancer therapy resistance.
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Pancreatic Cancer ARTNet Center
A national-center effort aims to understand why pancreatic cancer resist chemotherapy and to develop better treatment strategies for patients with this cancer.
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Personalized smartphone support to help adults in Laos quit smoking
This project offers a personalized smartphone program to help adult smokers in Laos stop using cigarettes.
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Aryl hydrocarbon receptor signaling in airway inflammation and asthma
This grant studies how the aryl hydrocarbon receptor (AhR) affects airway inflammation and asthma, focusing on airway smooth muscle and immune responses to see if targeting AhR could help people with asthma.
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Sustainable mobile health support to help people with HIV quit smoking
Researchers are testing a scalable smartphone-based program to help people with HIV quit smoking in real-world care settings.
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Tracking and Evaluation Core for Oklahoma Shared Clinical and Translational Resources
A program that helps Oklahoma researchers improve clinical and translational projects by tracking progress and measuring outcomes.
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Clinical Resources Core supports Oklahoma health research for better care
This grant funds a centralized core that helps researchers recruit people, manage samples, and access de-identified patient data to study and improve health in Oklahoma, including American Indian communities.
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Community Engagement and Outreach Core
A Health Center partner in Oklahoma is teaming up with communities and clinics to build better ways to do research that helps people with cancer, heart disease, diabetes, and other common conditions.
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Biostatistics, Epidemiology, and Research Design Core for improving clinical research quality
This grant funds expert help with study design, data analysis, and research reporting to improve clinical research quality in Oklahoma and neighboring states.
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Professional Development for Clinical Researchers in Oklahoma
A grant funds training and mentoring programs to help new and early-career clinicians and researchers in Oklahoma become independent investigators in clinical and translational science.
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Pilot projects to boost clinical and translational research in Oklahoma (for improving cancer, heart, and related health issues)
A program in Oklahoma funds small, innovative projects to quickly turn scientific ideas into better care for people with cancer, heart disease, arthritis, and related health problems.
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Administrative Core to Advance Translational Research in Oklahoma
A centralized program supports clinical and translational research in Oklahoma by training researchers, coordinating resources, and involving communities in trials.
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Oklahoma Shared Clinical and Translational Resources
A statewide program that speeds up health research by connecting clinicians, researchers, and data/resources to improve health in Oklahoma.
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OK-INBRE Developmental Research Program for Biomedical Investigators in Oklahoma
A statewide grant program supports early-career Oklahoma researchers with two main award paths to fund new biomedical projects and mentor scientists toward independent funding.
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