Role of MPST and mitochondria in oxygen-related neonatal airway disease
Official title: Role of MPST and Mitochondrial Bioenergetics in Hyperoxia-induced Neonatal Airway Disease
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-11452324 · Data updated 2026-11-12
A study in newborn airways looks at how a mitochondrial enzyme called MPST affects breathing problems in preterm babies exposed to high oxygen levels.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $152,388 |
| NIH project number | 1K08HL181276-01A1 |
| Project ID | NIH-11452324 on NIH RePORTER |
Who could benefit from this research
✓Could help
Preterm infants at risk of or diagnosed with bronchopulmonary dysplasia or related airway injury.
✕Less likely to help
Healthy full-term infants or adults without airway disease are unlikely to benefit from this specific neonatal airway study.
What this research studies
This research uses a 3D model of human neonatal airway tissue to study how excessive oxygen disrupts mitochondrial energy use and airway cell development. It focuses on the role of MPST as a key switch that can influence whether oxidative stress gets worse or gets resolved. The project combines lab-based modeling with analyses of mitochondrial function to understand how hyperoxia leads to poor airway remodeling and long-term respiratory problems. Findings could point to new ways to protect or repair the airway in babies at risk for bronchopulmonary dysplasia. The work is led by Abhrajit Ganguly at the University of Oklahoma Health Sciences Center and aims to translate cellular insights into better neonatal care.
Why it matters
Potential benefit: If successful, the work could guide new strategies to prevent or lessen airway damage in preterm infants exposed to high oxygen.
How similar studies have gone: Preliminary data using 3D neonatal airway models have shown meaningful links between hyperoxia, mitochondrial changes, and epithelial differentiation, supporting further development.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Ganguly, Abhrajit — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Ganguly, Abhrajit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.