Aryl hydrocarbon receptor signaling in airway inflammation and asthma
Official title: Aryl hydrocarbon receptor signaling in Airway Inflammation
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-11418015 · Data updated 2026-11-12
This grant studies how the aryl hydrocarbon receptor (AhR) affects airway inflammation and asthma, focusing on airway smooth muscle and immune responses to see if targeting AhR could help people with asthma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | July 19, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $571,224 |
| NIH project number | 5R01HL171245-03 |
| Project ID | NIH-11418015 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with allergic asthma or asthma-related airway inflammation could be affected by future applications of this research.
✕Less likely to help
People without asthma or those not involved in airway inflammation research may not directly benefit.
What this research studies
The project explores whether AhR activity in airway smooth muscle cells contributes to inflammation and airway hyperresponsiveness in asthma. It uses human airway smooth muscle cells and mouse models to examine how AhR activation changes gene expression, cell proliferation, and remodeling processes. Findings could reveal new ways to reduce airway stiffness and asthma symptoms by modulating AhR pathways.
Why it matters
Potential benefit: If successful, the research could lead to new strategies to lessen airway inflammation and hyperresponsiveness in asthma patients.
How similar studies have gone: Preliminary data suggest AhR influences airway cells and remodeling, indicating potential for translational impact, though further validation is needed.
Where this research is happening
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University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Venkatachalem, Sathish — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Venkatachalem, Sathish
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.