N-myristoylation and DNA damage response in Alzheimer’s disease
Official title: Role of Protein N-Myristoylation in Driving DNA Damage Response
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-11596299 · Data updated 2026-11-12
A study to understand how a protein modification called myristoylation affects the DNA damage response in people who have Alzheimer’s-related conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | February 1, 2025 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 4R00GM157498-03 |
| Project ID | NIH-11596299 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with Alzheimer’s-related dementia or Alzheimer’s syndrome who are willing to contribute biological samples or participate in related future studies.
✕Less likely to help
Healthy individuals or those without Alzheimer’s-related conditions are unlikely to directly benefit from this study.
What this research studies
This research will use advanced proteomics to identify and validate myristoylation events in proteins involved in DNA repair, with a focus on how NMT1 and NMT2 enzymes influence genome stability. The team will map how myristoylation alters interactions among DNA repair proteins and how that impacts cells exposed to different DNA damage triggers. By studying these processes in the context of Alzheimer’s-related conditions, the project aims to uncover mechanisms that could worsen or accelerate neurodegeneration. The findings may point toward targets for therapies that protect genome integrity in patients with Alzheimer’s disease dementia.
Why it matters
Potential benefit: If successful, the work could reveal new molecular targets to maintain genome stability in Alzheimer’s-related conditions and inform future therapies.
How similar studies have gone: Prior studies have shown that protein modifications influence DNA repair pathways, supporting the potential relevance of this approach.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Luong, Nho Cong — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Luong, Nho Cong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.