Sponsor or institution
Clinical trials and research at University of Calif-Lawrenc Berkeley Lab
As of November 12, 2026, Find a Trial lists 52 NIH-funded research projects at this institution, with $44.2 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 52NIH research projects
NIH-funded research (newest 40 of 52)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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A PET marker to study myelin and brain wiring in aging and Alzheimer’s disease
This study tests a new PET tracer to see how myelin health relates to aging and Alzheimer’s disease in people who may be at risk or affected.
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Structural Cell Biology Core for DNA Damage Response in Cancer
A core facility at a major university will provide advanced structural biology and AI-enabled imaging tools to study how DNA damage response proteins assemble and work in cancer cells.
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EMB Core at UC Berkeley boosts DNA repair protein research
A core laboratory at UC Berkeley is expanding its methods to produce high-quality DNA repair proteins and complexes, using advanced gene editing to study human cell lines.
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Regulation of double-strand break repair during replication stress
Aims to understand how human cells decide between safe and risky DNA repair during replication stress, which could influence cancer development and treatment.
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Mechanisms of single-strand DNA break repair and how PAR chains regulate them
A large, multi-institutional project is exploring how cells fix single-strand DNA breaks and how the PARP system influences this process, with implications for improving cancer treatments.
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Understanding how ERCC1-XPF is turned on to fix damaged DNA in cancer-related pathways
A researchers team is studying how a DNA-cutting enzyme (ERCC1-XPF) is activated in damaged DNA repair pathways to better understand cancer and responses to chemotherapy.
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Mechanisms of replication fork repair in cancer biology
A science team at a major university is studying how cells fix problems at the DNA replication fork to prevent cancer-causing mutations.
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Administrative Core supports advanced cancer research collaborations
This NIH grant funds an administrative core to help six cancer centers work together on structural biology of DNA repair to improve cancer research and potential treatments.
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Structural understanding of how DNA repair works in cancer
A large, multi-institution effort to map the detailed shapes and interactions of DNA repair machines to understand how they influence cancer and respond to therapies.
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Phenix software for crystal structures and cryo-EM
A long‑standing software package called Phenix will be renewed to help researchers accurately determine and study 3D structures of proteins and other macromolecules using crystallography and cryo-EM.
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Non-invasive infrared biodosimetry to triage radiation exposure
A painless imaging approach using FTIR-ATR on skin aims to quickly tell if someone has been exposed to radiation and how much, helping triage after an emergency.
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AqNWB: Directly collecting neurophysiology data in a standard format
This grant supports improving AqNWB so researchers can collect neurophysiology data directly in the NWB format, making data handling easier and more reliable for scientists and patients whose brain research could lead to better treatments.
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Open-source software to advance protein structure research worldwide
A US-wide resource will maintain and expand DIALS, a free software tool that helps scientists determine protein structures from X-ray data, speeding up discoveries that can affect health and disease understanding.
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Hybrid model-based and data-driven imaging for high-resolution cellular tomography
A new imaging approach blends advanced math and learning methods to produce crisper images of biomolecules inside cells.
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Understanding why some people age with intact thinking despite Alzheimer’s pathology
A long-term study looks at why some people keep their memory sharp even when brain changes linked to Alzheimer's are present.
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Understanding how distant DNA switches control gene activity in the body
This NIH grant explores how far-away DNA elements called enhancers turn genes on and off in human development and disease, using mouse models and other lab methods.
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Advanced analytics to map human viruses and their functions
A big data project using AI to map and understand the viruses living in and on humans, including which viruses infect humans, microorganisms, or come from food, and what genes they carry.
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New imaging method to guide radioactive cancer therapies using time-of-flight multi-photon signals
A new imaging approach could let doctors see and tailor radiopharmaceutical cancer treatments more accurately, even when using alpha-emitting drugs.
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Understanding how distant DNA elements shape birth defects
Researchers are studying how noncoding DNA regions that regulate genes may cause structural birth defects, aiming to explain previously unsolved cases.
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User-friendly data tools to share and reuse brain data
A grant to build easy software and data standards so brain and behavior data can be stored, shared, and reused by researchers and clinicians.
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Ultrafine, near-infrared imaging with avalanching nanoparticles for breast cancer cell studies
A new optical imaging method uses avalanching nanoparticles to see breast cancer cells in live tissue with very high detail while minimizing damage from light.
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Time-resolved, real-time views of how small molecules interact with proteins
Aiming to watch how drugs bind to proteins in real time, using advanced X-ray techniques to capture dynamic interactions in conditions similar to the human body.
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Mapping heart development enhancers at single-cell level to understand congenital heart disease
Researchers will map how heart development is controlled by gene-enhancer elements at single-cell resolution to better understand congenital heart disease in humans.
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Why thinking and memory change with age
Researchers are tracking older adults with brain scans and memory tests to learn why some people keep their memory even when Alzheimer's-related changes are present.
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Understanding the Viruses Inside and Around Us
This project uses advanced computer tools to learn more about all the different viruses living in and on people, including those that infect our microbes.
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Improving Imaging for Alpha Particle Cancer Treatments
This project aims to create a new imaging device that can better track powerful alpha particle treatments for cancers like leukemia, prostate, and pancreatic cancer.
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Protein-production support for cancer DNA-repair research
This program builds tools and services to help scientists produce high-quality proteins so they can understand how DNA repair fails in cancer.
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How cells repair stuck DNA-copying machinery
Researchers are learning how cells fix or bypass stalled DNA replication to better understand cancer and improve treatments.
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How PARP enzymes and PAR 'condensates' help cells repair damaged DNA
This research looks at how PARP enzymes make sugar-like PAR chains that create repair hubs to help fix damaged DNA in cancers.
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How cells repair broken DNA to improve cancer treatments
This work looks at how cells fix dangerous breaks in their DNA so people with BRCA1-related cancers might get better results from radiation and chemotherapy.
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How cells fix damaged DNA
Scientists are mapping how the cell's DNA-repair machinery works to help make cancer treatments more effective for people with cancer.
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Developing a new imaging device for targeted cancer therapy
This study is working on a new imaging device to help doctors see how a special cancer treatment, using a substance called 225Ac, moves around in the body, which could lead to better therapies for patients with acute myeloid leukemia and other cancers.
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Understanding Genetic Changes in Structural Birth Defects
This work aims to find new genetic causes for structural birth defects that are currently unexplained, helping families get answers.
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Understanding DNA enhancer switches that control gene activity in living tissues
This project maps how DNA 'enhancer' switches turn genes on and off across tissues to help explain genetic changes linked to disease.
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Improving a special X-ray technique to understand how important molecules in our bodies work
This project is making a powerful X-ray technique called XFMS even better and more available to scientists across the country, helping them learn more about how proteins and other biological molecules function.
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High-quality software for studying macromolecule structures
This study is all about creating better software tools to help scientists understand the structures of important molecules, which can lead to new treatments, and it also includes training to make sure researchers know how to use these tools effectively.
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Investigating how enzymes react using advanced imaging techniques
This study is looking at how certain proteins help produce oxygen in plants, using special imaging techniques to see how they work in real-time, which could help us understand important biological processes better.
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Improving the sensitivity of positron emission tomography imaging systems
This study is working on making PET scans better by using new technology to help doctors see clearer images, which could lead to more accurate diagnoses and better treatment plans for patients.
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Investigating how large biomolecules function using advanced imaging techniques
This study is exploring a new way to take detailed pictures of large molecules in our bodies to better understand how they work, using special lasers that won’t harm them, which could help scientists learn more about important biological processes.
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Improving how brain data is shared and used
This study is working on a new way to organize and share brain data so that researchers can better understand how our thoughts and memories work, making it easier for them to collaborate and learn from each other's findings.
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