Investigating how large biomolecules function using advanced imaging techniques
Official title: Cctbx.xfel: Serial crystallography computational methods aimed at biomolecular function
Funded at University of Calif-Lawrenc Berkeley Lab · NIH-11051212 · Data updated 2026-11-12
This study is exploring a new way to take detailed pictures of large molecules in our bodies to better understand how they work, using special lasers that won’t harm them, which could help scientists learn more about important biological processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Calif-Lawrenc Berkeley Lab NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | March 10, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $722,267 |
| NIH project number | 5R35GM151988-02 |
| Project ID | NIH-11051212 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to enzyme function or those interested in the biochemical mechanisms of large biomolecules.
✕Less likely to help
Patients with conditions unrelated to biomolecular function or those not involved in biochemical research may not benefit from this research.
What this research studies
This research focuses on using serial crystallography to uncover the structure and function of large biomolecules. By utilizing X-ray free-electron lasers, the team can capture rapid changes in biomolecules at physiological temperatures without damaging them. The project employs advanced computational methods to analyze vast amounts of data, allowing for quick adjustments during experiments. This innovative approach aims to enhance our understanding of complex biological processes and improve the efficiency of data collection.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding biomolecular functions, potentially impacting drug development and disease treatment.
How similar studies have gone: Previous research using similar serial crystallography techniques has shown promising results in understanding biomolecular structures, indicating a strong potential for success in this project.
Where this research is happening
-
University of Calif-Lawrenc Berkeley Lab
Berkeley, United States Active
Researchers
- Principal investigator: Sauter, Nicholas K — University of Calif-Lawrenc Berkeley Lab
- Study coordinator: Sauter, Nicholas K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.