EMB Core at UC Berkeley boosts DNA repair protein research
Official title: Core 1- Expression and Molecular Biology (EMB) Core
Funded at University of Calif-Lawrenc Berkeley Lab · NIH-11423282 · Data updated 2026-11-12
A core laboratory at UC Berkeley is expanding its methods to produce high-quality DNA repair proteins and complexes, using advanced gene editing to study human cell lines.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Calif-Lawrenc Berkeley Lab NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | September 27, 2001 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $814,912 |
| NIH project number | 2P01CA092584-26 |
| Project ID | NIH-11423282 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly; this is a core research facility supporting studies that may eventually benefit patients.
✕Less likely to help
Individuals will not directly participate in this core activity.
What this research studies
This core service supports researchers by producing both recombinant and endogenous DDR proteins and assemblies. It plans to adopt CRISPR knock-in to tag and modify proteins in human cells, enabling deeper functional studies. The work helps decipher how DNA repair machines operate, which could inform future therapies for related diseases.
Why it matters
Potential benefit: Advances in understanding DNA repair could lead to better treatments for conditions caused by DNA damage.
How similar studies have gone: Previous protein production cores have successfully enabled detailed structural studies of DDR complexes, suggesting this approach is productive.
Where this research is happening
-
University of Calif-Lawrenc Berkeley Lab
Berkeley, United States Active
Researchers
- Principal investigator: Tsai, Miaw-Sheue — University of Calif-Lawrenc Berkeley Lab
- Study coordinator: Tsai, Miaw-Sheue
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.