High-quality software for studying macromolecule structures
Official title: Phenix: providing high quality software to the research community for crystallography and cryo-EM
Funded at University of Calif-Lawrenc Berkeley Lab · NIH-11083127 · Data updated 2026-11-12
This study is all about creating better software tools to help scientists understand the structures of important molecules, which can lead to new treatments, and it also includes training to make sure researchers know how to use these tools effectively.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Calif-Lawrenc Berkeley Lab NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | May 3, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $1,402,923 |
| NIH project number | 5R24GM141254-05 |
| Project ID | NIH-11083127 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with diseases that could be targeted by new therapeutics developed through improved understanding of macromolecular structures.
✕Less likely to help
Patients with conditions unrelated to macromolecular structure or those not involved in research settings may not receive direct benefits from this research.
What this research studies
This research focuses on developing and providing advanced software tools for the scientific community to analyze the structures of macromolecules using techniques like crystallography and cryo-electron microscopy (cryo-EM). By improving the software capabilities, researchers can better understand how these macromolecules function and respond to various factors, which is crucial for therapeutic development. The Phenix software suite is designed to handle complex data from these methods, making it easier for scientists to derive meaningful insights from their experiments. The project also includes outreach and training to ensure that researchers can effectively utilize these tools.
Why it matters
Potential benefit: If successful, this research could significantly enhance the ability to develop new therapeutics by providing clearer insights into macromolecular structures.
How similar studies have gone: Previous research has shown success in using advanced software tools for structural biology, indicating that this approach is both tested and valuable.
Where this research is happening
-
University of Calif-Lawrenc Berkeley Lab
Berkeley, United States Active
Researchers
- Principal investigator: Adams, Paul David — University of Calif-Lawrenc Berkeley Lab
- Study coordinator: Adams, Paul David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.