Regulation of double-strand break repair during replication stress
Official title: P4 - Regulation of double-strand break repair during replication stress
Funded at University of Calif-Lawrenc Berkeley Lab · NIH-11423281 · Data updated 2026-11-12
Aims to understand how human cells decide between safe and risky DNA repair during replication stress, which could influence cancer development and treatment.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Calif-Lawrenc Berkeley Lab NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | September 27, 2001 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $450,218 |
| NIH project number | 2P01CA092584-26 |
| Project ID | NIH-11423281 on NIH RePORTER |
Who could benefit from this research
✓Could help
This grant is basic science; patient participation is not required.
✕Less likely to help
No direct patient participation is involved in this grant.
What this research studies
This project looks at how a key DNA repair system called NHEJ works when DNA replication is stressed, a situation common in cancer. By studying the structure and behavior of repair proteins, scientists hope to explain why cells sometimes fix breaks accurately and other times cause harmful changes. The team will use advanced imaging and structural biology to map how repair factors come together and how cell cycle signals shift repair choices. The goal is to uncover mechanisms that could eventually guide the development of safer cancer therapies. The work combines cell biology, biochemistry, and cutting-edge imaging to link basic science with potential clinical applications.
Why it matters
Potential benefit: Better understanding of DNA repair could lead to more precise cancer treatments with fewer side effects.
How similar studies have gone: Previous studies have shown that NHEJ is dynamic and context-dependent, supporting potential translational relevance.
Where this research is happening
-
University of Calif-Lawrenc Berkeley Lab
Berkeley, United States Active
Researchers
- Principal investigator: Paull, Tanya T — University of Calif-Lawrenc Berkeley Lab
- Study coordinator: Paull, Tanya T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.