Mechanisms of replication fork repair in cancer biology
Official title: P1-Mechanisms of replication fork repair
Funded at University of Calif-Lawrenc Berkeley Lab · NIH-11423278 · Data updated 2026-11-12
A science team at a major university is studying how cells fix problems at the DNA replication fork to prevent cancer-causing mutations.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Calif-Lawrenc Berkeley Lab NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | September 27, 2001 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $378,053 |
| NIH project number | 2P01CA092584-26 |
| Project ID | NIH-11423278 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not a patient-facing trial; however, findings could eventually inform cancer therapies that benefit patients with tumors having replication stress.
✕Less likely to help
This grant itself does not involve patient recruitment or direct care
What this research studies
This project looks at how cells handle replication stress at the DNA replication fork and how the replisome and checkpoint signals influence repair and restart. Researchers will study ATR signaling, CMG helicase activity, and polymerase coupling to see how fork progression is controlled under stress. The work aims to map how fork remodeling and damage tolerance pathways interact with replication stress to maintain genome integrity, with potential implications for cancer therapies. By understanding these processes, the study could reveal new vulnerabilities in cancer cells that rely on replication stress responses.
Why it matters
Potential benefit: Insights into how replication stress response works could guide the development of more precise cancer treatments that target replication vulnerabilities.
How similar studies have gone: Previous work has shown replication-stress pathways are linked to cancer vulnerabilities, supporting the potential impact of this approach
Where this research is happening
-
University of Calif-Lawrenc Berkeley Lab
Berkeley, United States Active
Researchers
- Principal investigator: Eichman, Brandt F — University of Calif-Lawrenc Berkeley Lab
- Study coordinator: Eichman, Brandt F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.