Structural Cell Biology Core for DNA Damage Response in Cancer
Official title: Core 2- Structural Cell Biology (SCB) core
Funded at University of Calif-Lawrenc Berkeley Lab · NIH-11423283 · Data updated 2026-11-12
A core facility at a major university will provide advanced structural biology and AI-enabled imaging tools to study how DNA damage response proteins assemble and work in cancer cells.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Calif-Lawrenc Berkeley Lab NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | September 27, 2001 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $937,754 |
| NIH project number | 2P01CA092584-26 |
| Project ID | NIH-11423283 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cancers where DNA damage response pathways are relevant or altered
✕Less likely to help
For patients whose cancers do not involve DDR pathways or where core access is not applicable to their research, direct benefits may be limited
What this research studies
This NIH P01 grant supports a Structural Cell Biology Core that combines cutting-edge structural biology, super-resolution imaging, and AI-assisted modeling to map how DDR proteins form complexes in cancer. The core aims to integrate AI predictions with experimental methods to reveal how these complexes change shape and function when DNA is damaged or modified. Researchers from multiple labs can access the core’s resources to study DDR structures in cells and validate findings in cellular systems. The work is designed to make it easier for cancer researchers to understand the physical basis of genome maintenance and to inform potential therapies. Participation would be through collaboration with the core scientists and access to services and expertise for structural analysis in relevant studies.
Why it matters
Potential benefit: If successful, this core could enable breakthroughs in understanding DDR protein structures, potentially guiding new cancer therapies.
How similar studies have gone: Other projects using integrative structure biology and AI-enhanced modeling have shown promise in outlining DDR complexes, but this core emphasizes broad access and AI integration for structural insights
Where this research is happening
-
University of Calif-Lawrenc Berkeley Lab
Berkeley, United States Active
Researchers
- Principal investigator: Hura, Gregory L — University of Calif-Lawrenc Berkeley Lab
- Study coordinator: Hura, Gregory L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.