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Clinical trials and research at Unity Health Toronto

• 39Clinical trials
• 1New in 30 days
• 22Countries

Newest trials

All recruiting trials (39)

• Friends and family training for those at risk of suicide

  A six-week program tests whether training for caregivers can help them support a loved one at risk of suicide while also taking care of their own mental health.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT07902089

• Supporting social and economic equity to help young people move out of homelessness and thrive

  This pilot will try an 18-month wraparound program of job help, housing supports, grocery supplements, coaching and community connection for 18–24-year-olds who recently experienced homelessness to see if they engage and find it helpful.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT07419282

• Digital app to support oncologist‑initiated genetic testing

  This project tests a digital app (GA‑Mainstream) to help oncologists offer germline genetic testing to adults with breast, prostate, colon, or other GI cancers.

  Recruiting at 2 sites Unity Health Toronto · Toronto, Ontario and 1 other locations · NCT07387263

• TreatResp: adaptive study of breathing infections therapies for community care

  This trial tests baloxavir vs. standard care in adults with influenza or similar respiratory infections to see if new treatments help people recover faster when kept at home.

  Recruiting Phase 3 Unity Health Toronto · Toronto, Ontario · NCT07314905

• MDMA for severe chronic neuropathic pain

  This will try a single oral dose of MDMA combined with psychotherapy to see if it reduces pain and improves function in adults with moderate-to-severe chronic neuropathic pain that hasn't responded to standard medications.

  Recruiting Phase 2 Unity Health Toronto · Toronto, Ontario · NCT07301632

• AbClo abdominal binder's effects on breathing mechanics in ventilated patients with an open abdomen

  This test will see if adjusting the AbClo abdominal binder changes lung pressures, lung volume, and breathing function in adults on ventilators with an open abdomen.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT07154589

• GLP-1 receptor agonist in people on maintenance dialysis

  This test will see if weekly semaglutide is safe and doable for people on long-term dialysis who have type 2 diabetes.

  Recruiting at 2 sites Phase 4 Unity Health Toronto · Toronto, Ontario and 1 other locations · NCT07017270

• Using rectal Methadone for pain management after spine surgery

  This study is testing if using rectal Methadone can help adults manage pain better after spine surgery compared to a placebo.

  Recruiting Phase 4 Unity Health Toronto · Toronto, Ontario · NCT06843174

• Corticosteroid injection for knee surgery patients

  This study is testing if giving corticosteroid injections to the other knee can help people with both knees affected by osteoarthritis recover better after knee surgery.

  Recruiting Phase 1/2 Unity Health Toronto · Toronto, Ontario · NCT06809998

• Digital health tools for adults with treatment-resistant depression

  This study is testing if digital health tools, like apps and wearable devices, can help adults with treatment-resistant depression track their symptoms and treatment responses while they receive care.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT06732089

• Using psilocybin to help manage chronic neuropathic pain

  This study is testing if psilocybin can help adults with chronic nerve pain find relief when other medications haven't worked.

  Recruiting Phase 2 Unity Health Toronto · Toronto, Ontario and 1 other locations · NCT06731335

• Multiplo HIV and syphilis self-test for adults

  This project will see if adults seeking HIV or syphilis testing can correctly use the Multiplo HIV/syphilis self-test to get accurate results.

  Recruiting at 3 sites Unity Health Toronto · Victoria, British Columbia and 2 other locations · NCT06716450

• Using infrared light to improve memory in people with mild cognitive impairment

  This study is testing if using infrared light therapy can help improve memory in people with mild cognitive impairment from Alzheimer's disease.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT06618807

• Brief Skills for Safer Living: one-session therapy for people with suicidal thoughts

  This trial will test whether one brief, virtual Brief-SfSL session plus usual care helps adults in Canada with recent suicidal thoughts reduce suicidal thinking compared with usual care alone.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT06571916

• Using Whole Blood for Trauma Patients in Canada

  This study tests if giving whole blood right away to trauma patients in Canada helps them survive better than the usual blood transfusions.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT06495294

• Genetics Navigator: a digital platform to guide people through genetic testing

  This randomized trial will test whether the Genetics Navigator digital platform helps adults and parents of children referred for clinical genetic testing have less distress and a smoother testing process compared with usual genetics appointments.

  Recruiting at 3 sites Unity Health Toronto · Toronto, Ontario and 2 other locations · NCT06455384

• Intrinsic Respiratory Rate Test During Mechanical Ventilation to Help Spontaneous Breathing and Extubation

  This pilot randomized trial tests a brief intrinsic breathing rate check during ventilation to see if it helps patients with reverse triggering breathe on their own and be extubated sooner.

  Recruiting Unity Health Toronto · Toronto, Ontario and 1 other locations · NCT06445049

• Assessing surgery risk through a walking test

  This study is testing if a six-minute walking test can help predict the risk of complications for patients over 40 who are having non-heart surgery.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT06412367

• Individualized physical activity program for treatment-resistant depression

  This study is testing a personalized exercise program to see if it can help adults with treatment-resistant depression feel better when combined with their usual treatment.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT06404320

• Prophylactic treatment for heavy menstrual bleeding in women with von Willebrand disease

  This study tests if a new treatment can help women with von Willebrand disease who have heavy menstrual bleeding feel better during their periods.

  Recruiting at 2 sites Phase 3 Unity Health Toronto · Kingston, Ontario and 1 other locations · NCT06205095

• Exploring brain activity changes in treatment-resistant depression

  This study is testing how a brain stimulation treatment can help people with depression who haven't found relief from other therapies by looking at changes in brain activity and memory.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT06163625

• Comparing knee joint replacement to surgical fixation for elderly patients with distal femur fractures

  This study is testing whether total knee joint replacement or surgical fixation works better for older patients with broken thigh bones near their knee to help them feel less pain and improve their daily activities.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT05805774

• Healthy food vouchers to improve blood sugar control in low-income individuals with diabetes

  This study is testing if giving healthy food vouchers to low-income people with diabetes can help lower their blood sugar levels.

  Recruiting Phase 3 Unity Health Toronto · Toronto · NCT05776420

• Virtual self-management education for type 1 diabetes

  This study tests if a virtual support program can help people with type 1 diabetes manage their blood sugar better without needing to go to in-person appointments.

  Recruiting at 8 sites Unity Health Toronto · Kitchener, Ontario and 8 other locations · NCT05756829

• Using tranexamic acid to help people with symptomatic subdural hematoma

  This trial tests whether tranexamic acid can help reduce bleeding and speed recovery in adults 45 and older with symptomatic subdural hematoma.

  Recruiting Phase 3 Unity Health Toronto · Toronto, Ontario · NCT05713630

• Training respiratory muscles during neck flexion for patients on mechanical ventilation

  This study tests if combining breathing exercises with neck flexion can help patients on mechanical ventilation strengthen their respiratory muscles and successfully wean off the ventilator.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT05710432

• Integrated suicide and trauma therapy for adults with childhood trauma and suicidal thoughts

  This pilot will test a 12-week program that combines brief safety and coping skills with trauma-focused therapy to reduce suicide risk in adults who have a history of childhood trauma and current suicidal thoughts.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT05613972

• Using intravitreal topotecan to treat severe retinal detachment complications

  This study is testing if a new injection of topotecan can help people with severe retinal detachment complications who haven't had success with regular surgery.

  Recruiting at 2 sites Phase 2 Unity Health Toronto · Toronto, Ontario and 1 other locations · NCT05523869

• Using Temporal Interference to Treat Major Depressive Disorder

  This study is testing a new non-invasive treatment using brain stimulation to see if it can help people with major depression feel better.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT05295888

• Monitoring respiratory muscles in patients with spinal cord injury during mechanical ventilation

  This study looks at how spinal cord injuries affect breathing muscles in patients on mechanical ventilation to see if they can recover and improve their breathing over time.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT05207046

• Identifying and treating sleep disorders in patients with acute respiratory failure

  This study is trying to find out if sleep problems are common in people with severe breathing issues and how these problems affect their recovery and chances of going back to the hospital.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT05011877

• Comparing blood transfusion strategies in younger patients undergoing heart surgery

  This study tests which blood transfusion method works better for younger patients having heart surgery to help them recover more smoothly and avoid complications.

  Recruiting at 47 sites Unity Health Toronto · Portland, Maine and 53 other locations · NCT04754022

• Assessing lung recruitment in ARDS patients using electrical impedance tomography

  This study is testing if a new method using electrical signals can help doctors see how well the lungs of patients with ARDS can be opened up for better breathing while they are on a ventilator.

  Recruiting at 3 sites Unity Health Toronto · São Paulo and 3 other locations · NCT04460859

• Comparing knee replacement to surgical fixation for elderly patients with distal femur fractures

  This study is trying to see if knee replacement or surgical fixation works better for older patients with certain types of thigh bone fractures.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT04076735

• Optimizing Ventilation for Patients with Acute Respiratory Distress Syndrome

  This study tests a new way of using ventilators to see if it can help patients with acute respiratory distress syndrome, including those with COVID-19, live longer and breathe better.

  Recruiting at 33 sites Unity Health Toronto · New York, New York and 32 other locations · NCT03963622

• Evaluating low versus standard doses of epinephrine for out-of-hospital cardiac arrest

  This study tests whether giving a lower dose of epinephrine can help adults who have a cardiac arrest outside of the hospital more effectively than the standard higher dose.

  Recruiting at 9 sites Phase 4 Unity Health Toronto · Victoria, British Columbia and 8 other locations · NCT03826524

• Fixing the hip socket with plates and screws versus adding a hip replacement for older adults with a broken acetabulum

  This study will try two surgical approaches—ORIF alone versus ORIF plus a primary total hip replacement—in people 60 and older with an acute displaced acetabular (hip socket) fracture to see which gives better pain, function, and quality of life.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT03713853

• Dopamine D2/D3 receptor binding in treatment-resistant, non-resistant depression, and healthy adults

  This project will use PET scans to see if dopamine D2/D3 receptor binding differs between adults with treatment-resistant depression, non-resistant major depression, and healthy volunteers.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT03537794

• Comparing High Flow Nasal Cannula and Non-Invasive Ventilation for COPD Exacerbations

  This study is testing whether High Flow Nasal Cannula or Non-Invasive Ventilation works better to help people with COPD feel more comfortable and breathe easier during flare-ups.

  Recruiting Unity Health Toronto · Toronto, Ontario · NCT03033251

Quick answers

How many clinical trials run by Unity Health Toronto are recruiting right now?

39, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 22 countries. The most sites are in Canada (39 trials), Spain (3 trials), United States (2 trials), Italy (2 trials), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 4, Phase 4: 3, Phase 2: 3, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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