Monitoring respiratory muscles in patients with spinal cord injury during mechanical ventilation
Role of ACCESsory Muscles in Mechanically Ventilated Patients After Spinal Cord Injury and Trauma: a Physiological Study - The ACCESSIT Study
This study looks at how spinal cord injuries affect breathing muscles in patients on mechanical ventilation to see if they can recover and improve their breathing over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 16 Years and up |
| Sex | All |
| Sponsor | Unity Health Toronto Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT05207046 on ClinicalTrials.gov |
What this trial studies
This observational study aims to characterize and monitor the structure, activation, and function of respiratory muscles in patients with traumatic spine lesions requiring mechanical ventilation. It focuses on understanding how spinal cord injuries affect respiratory muscle coordination and function, particularly during the acute phase in intensive care. By assessing these factors over time, the study seeks to identify potential for recovery and training of respiratory muscles, which could lead to improved clinical outcomes for patients. The study will utilize non-invasive monitoring techniques to gather data on respiratory muscle performance.
Who should consider this trial
Good fit: Ideal candidates include adults aged 16 and older with traumatic spine lesions requiring invasive mechanical ventilation.
Not a fit: Patients who are expected to have treatment withdrawn within 24 hours or have chronic respiratory failure prior to the injury may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of respiratory muscle recovery in spinal cord injury patients, potentially leading to improved weaning from mechanical ventilation.
How similar studies have performed: While the study addresses a critical gap in understanding respiratory muscle function in spinal cord injury, similar approaches have shown promise in other contexts, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Presence of traumatic spine lesion (with and without spinal cord injury) * Requiring invasive mechanical ventilation, via oro-tracheal or tracheostomy tube, * 16 years of age or older * Patient or substitute decision maker able to provide consent Exclusion Criteria: * Expected withdrawal of treatments within 24 hours of screening * Chronic respiratory failure already treated with mechanical ventilation before the injury * Documented pre-existing neuromuscular diseases
Where this trial is running
Toronto, Ontario
- Unity Health Toronto - St. Michael's Hospital — Toronto, Ontario, Canada (Recruiting)
Study contacts
- Study coordinator: Laurent Brochard, MD, PhD
- Email: Laurent.Brochard@unityhealth.to
- Phone: 416-864-5686
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.