Monitoring respiratory muscles in patients with spinal cord injury during mechanical ventilation
Official title: Role of ACCESsory Muscles in Mechanically Ventilated Patients After Spinal Cord Injury and Trauma: a Physiological Study - The ACCESSIT Study
Run by Unity Health Toronto · NCT05207046 · Data updated 2026-11-12
This study looks at how spinal cord injuries affect breathing muscles in patients on mechanical ventilation to see if they can recover and improve their breathing over time.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 16 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Unity Health Toronto Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Status | Recruiting |
| Started | December 17, 2021 |
| Main results expected | June 2026 |
| Study ends | June 2026 |
| Registry record updated | May 20, 2025 |
| Trial ID | NCT05207046 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 16 and older with traumatic spine lesions requiring invasive mechanical ventilation.
✕Probably not a fit
Patients who are expected to have treatment withdrawn within 24 hours or have chronic respiratory failure prior to the injury may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to characterize and monitor the structure, activation, and function of respiratory muscles in patients with traumatic spine lesions requiring mechanical ventilation. It focuses on understanding how spinal cord injuries affect respiratory muscle coordination and function, particularly during the acute phase in intensive care. By assessing these factors over time, the study seeks to identify potential for recovery and training of respiratory muscles, which could lead to improved clinical outcomes for patients. The study will utilize non-invasive monitoring techniques to gather data on respiratory muscle performance.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of respiratory muscle recovery in spinal cord injury patients, potentially leading to improved weaning from mechanical ventilation.
How similar studies have gone: While the study addresses a critical gap in understanding respiratory muscle function in spinal cord injury, similar approaches have shown promise in other contexts, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Presence of traumatic spine lesion (with and without spinal cord injury) * Requiring invasive mechanical ventilation, via oro-tracheal or tracheostomy tube, * 16 years of age or older * Patient or substitute decision maker able to provide consent Exclusion Criteria: * Expected withdrawal of treatments within 24 hours of screening * Chronic respiratory failure already treated with mechanical ventilation before the injury * Documented pre-existing neuromuscular diseases
Where it's running
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Unity Health Toronto - St. Michael's Hospital
Toronto, Ontario, Canada Recruiting
Study contacts
- Study coordinator: Laurent Brochard, MD, PhD
- Email: Laurent.Brochard@unityhealth.to
- Phone: 416-864-5686
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Lung volume changes with synchronized noninvasive ventilator support in preterm infants
This study will use a noninvasive imaging belt to see if synchronized ventilator inflations produce larger lung volumes than unsynchronized or backup inflations in very preterm infants on sNIPPV.
-
Comparing two ventilation modes for ICU patients
This study is trying to see which breathing support method, SIMV or MMV, works better for stable adult ICU patients by switching them between the two and monitoring their lung function.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.