Identifying and treating sleep disorders in patients with acute respiratory failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients experiencing acute hypercapnic respiratory failure, particularly those with chronic conditions like COPD and obesity-related hypoventilation. It aims to identify sleep disorders during unplanned hospital admissions and assess their impact on readmission rates and mortality. Participants will undergo sleep studies using EEG and oximetry both in the hospital and two months post-discharge. Additionally, the study will evaluate the effects of high-flow nasal cannula therapy on sleep abnormalities.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients requiring an unplanned hospitalization or emergency room visit due to an acute hypercapnic respiratory failure exacerbation (AHRF), not on home noninvasive or invasive ventilation, neuromuscular disease (e.g., spinal cord injury) or central nervous system disorders (e.g., cerebral vascular accident, Alzheimer), absence of tracheotomy, and non-morbidly obese.

Exclusion Criteria:

* Patients with AHRF due to drug overdose
* Ventilatory support (noninvasive or invasive ventilation) is needed before or during the sleep studies or if an acute deterioration (e.g., cerebral vascular accident, cardiac arrest) happens before or during the sleep studies.

Where it's running

• St. Michael's Hospital
  Toronto, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Laurent Brochard, MD, PhD — Unity Health Toronto - St. Michael's Hospital
• Study coordinator: Laurent Brochard, MD, PhD
• Email: Laurent.Brochard@unityhealth.to
• Phone: 416-864-5686

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.