Comparing High Flow Nasal Cannula and Non-Invasive Ventilation for COPD Exacerbations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of High Flow Nasal Cannula (HFNC) compared to Non-Invasive Ventilation (NIV) in patients experiencing exacerbations of Chronic Obstructive Pulmonary Disease (COPD) and acute hypercapnic respiratory failure. Participants will be randomly assigned to receive both treatments in a controlled setting, with each intervention lasting up to 30 minutes. The study aims to assess the physiological responses and tolerability of each method in a Medical-Surgical ICU environment. The primary focus is on improving patient comfort and respiratory function during acute episodes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. COPD exacerbation and acute hypercapnic respiratory failure with acute respiratory failure defined by

   * Respiratory acidosis (pH ≤7.35 and PaCO2 ≥45 mmHg);
   * Respiratory rate≥20 breaths/min;
   * Activation of accessory respiratory muscles;
2. Undergone at NIV or HFNC since their admission
3. English speaking
4. Adult patient with age \> 40 year old.

Exclusion Criteria:

1. Severe respiratory acidosis defined by pH\<7.25
2. Decreased level of consciousness (Glasgow Coma Score Scale \< 11)
3. Urgent intubation required
4. Pneumothorax with pleural drainage and persistent air leak
5. Hemodynamic instability requiring vasopressors
6. Uncooperative
7. Patients with skin or chest wall or abdominal trauma (potentially worsened by placement of a surface sensor)
8. Clinical judgement of the attending physician
9. Body mass index \> 40 kg/m2

Where it's running

• St. Michael's Hospital
  Toronto, Ontario, Canada Recruiting

Study contacts

• Study coordinator: Laurent Brochard, MD
• Email: BrochardL@smh.ca
• Phone: +1 416 864 5686

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.