Training respiratory muscles during neck flexion for patients on mechanical ventilation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of inspiratory muscle training (IMT) combined with neck flexion exercises in patients who are receiving mechanical ventilation. It aims to strengthen respiratory muscles, particularly in patients who have struggled with weaning from ventilators. The approach includes baseline measurements using ultrasound and electromyography to assess muscle function, followed by weekly training sessions until successful weaning or a maximum of four weeks. The study focuses on patients who can spontaneously trigger the ventilator and are in stable clinical conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients receiving invasive MV via endotracheal tube who had failed a planned extubation or failed at least three spontaneous breathing trials (SBTs) or receiving MV via tracheostomy (who required tracheostomy because of difficult or prolonged weaning, failed extubation and/or prolonged ventilation) and able to spontaneously trigger the ventilator.
* Over or equal to 16 years of age
* Tolerating levels of pressure support of 10 cmH2O or lower (or equivalent support in NAVA or PAV+) for at least 15 minutes
* In stable clinical and hemodynamic conditions and adequate level of oxygenation (cardiac frequency ≤ 140 beats/minute, systolic blood pressure 90-160 mmHg, no or minimal vasopressors, PaO2/FiO2 over or equal to 150 mmHg)
* Able to understand and follow simple verbal instructions

Exclusion Criteria:

* Patients with a previously diagnosed severe neuromuscular disorder (such as amyotrophic lateral sclerosis, muscular dystrophy, multiple sclerosis, myasthenia gravis or spinal cord injury)
* Patients with chronic respiratory failure already ventilated before ICU admission
* Patients unable to collaborate or understand instructions

Where it's running

• St. Michael's Hospital
  Toronto, Ontario, Canada Recruiting

Study contacts

• Study coordinator: Laurent Brochard, MD, PhD
• Email: Laurent.Brochard@unityhealth.to
• Phone: 416-864-5686

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.