Intrinsic Respiratory Rate Test During Mechanical Ventilation to Help Spontaneous Breathing and Extubation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study enrolls 70 adults with reverse triggering who are on controlled ventilation in two Toronto ICUs. After screening, participants are randomized to standard care or a brief intervention that includes a short intrinsic respiratory rate assessment and a possible 5-minute pressure-support test if criteria are met. The goal is to see whether identifying intrinsic rate improves transition to spontaneous breathing and successful extubation. Safety excludes those on continuous neuromuscular blockade or with severe metabolic acidosis. The trial uses a deferred consent model and is led by Unity Health Toronto with sites at St. Michael's and Toronto Western Hospitals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (aimed at equal number of men and woman) sedated and under controlled ventilation having reverse triggering.

Exclusion Criteria:

* under current use of continuous neuromuscular blocking agent or severe metabolic acidosis (Ph\<7.25) at the time of study procedure.

Where it's running

• St. Michael's Hospital
  Toronto, Ontario, Canada Recruiting
• Toronto Western Hospital
  Toronto, Ontario, Canada Not yet recruiting

Study contacts

• Principal investigator: Laurent Brochard — Unity Health Toronto - St. Michael's Hospital
• Study coordinator: Laurent Brochard, MD
• Email: laurent.brochard@unityhealth.to
• Phone: 4168645686

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.