Sponsor or institution
Clinical trials and research at Texas Biomedical Research Institute
As of November 12, 2026, Find a Trial lists 61 NIH-funded research projects at this institution, with $52.2 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 61NIH research projects
NIH-funded research (newest 40 of 61)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Targeting human HIV latency with super-enhancer RNA targets
A short, patient-friendly plan to explore how special RNA molecules in immune cells control HIV hiding in the body and how we might disrupt that to help control the virus.
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Pathways to trigger protective MAIT cell responses against bacterial infections
A study to figure out which bacterial metabolite antigens activate MAIT cells through MR1 to defend against TB and tularemia.
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IL-21 therapy to boost lung immunity in HIV/TB co-infection
A study tests an IL-21-based therapy added to HIV treatment to help the lungs control TB and reduce HIV persistence in people (or animal models that simulate them).
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Focused ultrasound to open the blood-brain barrier and reduce HIV reservoirs in the brain
A new approach uses gentle ultrasound to temporarily open the brain’s protective barrier so HIV medicines can reach the brain and shrink hidden virus reservoirs in people living with HIV.
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Macrophage biology and metabolism in TB infection
Researchers are studying human lung macrophages to understand how they regulate immune responses and support or limit tuberculosis infection, with the goal of improving treatments that help the body fight TB.
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Understanding how genetics and immunity shape chikungunya brain disease
A research project uses genetically diverse mice to learn why chikungunya virus causes brain inflammation in some people and how immune responses contribute to this disease.
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Mtb metabolites to spark MAIT cell protection in TB
This grant looks at how tiny Mtb compounds can trigger MAIT cells to fight tuberculosis in people.
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Attenuated tuberculosis vaccine study in HIV co-infected individuals
A new, weakened tuberculosis vaccine approach is being tested to see if it can safely and effectively protect people who also have HIV.
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Intranasal live-attenuated vaccine against Lassa virus
A nasal vaccine approach using live-attenuated Newcastle disease virus to protect people at risk from Lassa fever.
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Tuberculosis vaccine strategy to protect the lungs in primates
A new vaccine approach using a weakened M. tuberculosis strain aims to protect the lungs from TB by creating strong early lung defenses in people at risk.
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How HIV mutates: host genes that shape HIV mutation and drug resistance
Researchers are studying how human APOBEC3 enzymes influence HIV mutations in people living with HIV, aiming to understand why some viral changes lead to drug resistance.
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Epigenetic changes linked to gut barrier problems in HIV, and how to fix them
A study exploring how DNA methylation and open chromatin in the gut lining contribute to barrier dysfunction in people living with HIV onART, with potential ways to improve gut health and reduce inflammation.
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Targeting indoleamine pathways to boost immunity in people with HIV and tuberculosis
This project tests whether blocking an enzyme called IDO can strengthen immune responses against tuberculosis in the setting of HIV, using animal models that mirror human disease.
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How tuberculosis spreads in the body
Researchers are using mouse experiments plus computer models to learn how TB moves from the lung to other parts of the body, aiming to help children and people with weakened immune systems.
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Breeding and caring for rhesus macaques used in HIV/AIDS research
This project breeds and cares for healthy, well‑characterized rhesus macaques so researchers can develop better HIV/AIDS vaccines and treatments for people living with HIV.
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Pathogen-free rhesus monkey colony to support HIV/AIDS and COVID research
This project keeps and breeds pathogen-free rhesus monkeys so scientists can develop better vaccines and treatments for people with HIV/AIDS and COVID-19.
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Gene therapy that targets brain immune cells to remove HIV
Develops a gene-editing approach delivered to brain immune cells to try to remove hidden HIV in people living with HIV.
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How the immune protein IDO weakens defenses in tuberculosis and whether blocking it helps
This work looks at whether blocking a protein called IDO can help the immune system fight tuberculosis in people and in animal models, including TB/HIV co-infection.
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Rectal immunization to block HIV at the mucosal entry point
Aiming to create long-lasting immune defenses in the rectal lining to help prevent HIV infection.
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How COVID-19 affects people living with HIV
Researchers are using monkey models to find out whether having HIV changes how COVID-19 looks and how severe it can be for people with HIV.
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Testing a new tuberculosis vaccine for people with HIV
This study is testing a new vaccine to help protect people with both tuberculosis and HIV, aiming to create a stronger and longer-lasting immune response than the current vaccine, and participants will receive the vaccine and be monitored for their health and immune reactions.
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Developing models to understand infectious diseases.
This study is working on building models that mimic infectious diseases to help researchers find better treatments, so patients can eventually benefit from new therapies that fight these illnesses.
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Developing models to understand infectious diseases.
This study is all about building models that mimic infectious diseases so researchers can learn how they work and find better treatments, which could help patients like you in the future.
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Developing models to understand infectious diseases.
This study is all about building models that mimic infectious diseases so researchers can learn how they work and find new treatments that could help patients like you in the future.
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How mixing between blood fluke species changes their genes
Researchers are looking at whether genes from cattle blood flukes have mixed into human blood flukes and how that might affect infections in people.
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Non-coding RNAs that help the body control HIV
This project looks at whether certain long non-coding RNAs help some people naturally keep HIV under control by studying blood samples from people with and without HIV.
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Understanding how to better control tuberculosis in the lungs before it forms granulomas
This study is looking at new ways to create a better vaccine for tuberculosis (TB) that could help your body fight the disease more effectively, using a modified version of the bacteria that causes TB to boost your immune response.
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A Long-Lasting HIV Vaccine for Initial Infection Sites
This project is working to create a strong, long-lasting vaccine that protects against HIV right where the virus tries to enter the body.
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How Immune Cells Fight Tuberculosis Infection
This research explores how our lung's immune cells work and how tuberculosis bacteria try to outsmart them, hoping to find new ways to treat the infection.
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Investigating the effects of IL-21 treatment alongside ART and TB therapy in HIV and TB co-infection.
This study is looking at how a special protein called IL-21, when used with regular HIV and TB treatments, can help boost the immune system in people who have both HIV and TB, making them healthier and less likely to get sick again.
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Promoting careers in bioscience through teacher training and student engagement
This study is all about helping teachers and students learn more about exciting careers in bioscience, so they can inspire the next generation of scientists and researchers through special programs and resources.
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Understanding how tuberculosis germs activate our immune cells
This research looks for new ways to boost our body's natural defenses against tuberculosis by understanding how the bacteria trigger special immune cells.
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Improving immune responses to tuberculosis in people with HIV
This study is looking at how changing certain immune pathways might help people with both tuberculosis (TB) and HIV fight these infections better, using macaque models to find new ways to improve treatment for patients dealing with both conditions.
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Understanding how certain enzymes affect HIV mutations and immunity
This study is looking at how certain enzymes in our bodies affect the mutations of the HIV-1 virus, using data from around 37,000 patients to understand how these changes can influence how well treatments work for different people.
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A vaccine that targets the mucosal surfaces to prevent HIV infection
This study is testing a new type of HIV vaccine that aims to create strong protection right where the virus usually enters the body, using special cells to help build a lasting immune response, which could lead to better health for people at risk of HIV.
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Developing a vaccine to prevent HIV infection at mucosal sites
This study is testing a new vaccine designed to help your body fight HIV right at the spots where the virus usually enters, with the hope of giving you better protection against getting infected.
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Understanding how tuberculosis spreads in the body
This study is looking at how the tuberculosis bacteria spread in the lungs and possibly to other parts of the body, especially to help improve understanding and treatment for young children and people with weakened immune systems.
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Improving tuberculosis care and research for older adults and those with diabetes
This study is all about helping older adults and people with diabetes better understand and manage tuberculosis (TB), and it offers training for new researchers to learn how to improve TB care, especially for those living near the US-Mexico border.
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Advanced imaging techniques for studying animal models
This study is all about helping researchers learn new ways to take pictures of cells and tissues in animals, especially monkeys, so they can better understand how our bodies work and improve medical research.
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Training program using animal models to improve tuberculosis research
This study is all about teaching people how to use animal models, like mice and monkeys, to better understand tuberculosis and develop new treatments and vaccines, while also making sure to follow ethical guidelines in research.
Find the studies that fit you
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