Understanding how certain enzymes affect HIV mutations and immunity
Official title: Viral and host determinants of donor-specific anti-HIV/SIV immunity mediated by APOBEC3-enzyme
Funded at Texas Biomedical Research Institute · NIH-11123364 · Data updated 2026-11-12
This study is looking at how certain enzymes in our bodies affect the mutations of the HIV-1 virus, using data from around 37,000 patients to understand how these changes can influence how well treatments work for different people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Biomedical Research Institute NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | June 21, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $822,404 |
| NIH project number | 5R01AI179465-02 |
| Project ID | NIH-11123364 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are undergoing antiretroviral therapy.
✕Less likely to help
Patients who are not infected with HIV or those who do not have access to antiretroviral therapy may not benefit from this research.
What this research studies
This research investigates how human enzymes, specifically APOBEC3D, APOBEC3F, and APOBEC3G, influence mutations in the HIV-1 virus. By analyzing genetic data from approximately 37,000 patients, the study aims to uncover how variations in both the virus and the host's enzymes lead to different immune responses and treatment outcomes. The approach combines computational analysis and experimental techniques to identify the specific factors that contribute to the effectiveness of these enzymes against HIV. This could help tailor treatments based on individual genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to more effective personalized treatments for HIV, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the role of APOBEC3 enzymes in HIV mutation, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Texas Biomedical Research Institute
San Antonio, United States Active
Researchers
- Principal investigator: Ebrahimi, Diako — Texas Biomedical Research Institute
- Study coordinator: Ebrahimi, Diako
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.