Developing a vaccine to prevent HIV infection at mucosal sites
Official title: Intrarectal Immunization for a Barrier to Mucosal HIV Infection
Funded at Texas Biomedical Research Institute · NIH-11077331 · Data updated 2026-11-12
This study is testing a new vaccine designed to help your body fight HIV right at the spots where the virus usually enters, with the hope of giving you better protection against getting infected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Biomedical Research Institute NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | April 19, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $903,547 |
| NIH project number | 5R01AI179412-02 |
| Project ID | NIH-11077331 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at high risk of HIV exposure, particularly those with mucosal vulnerabilities.
✕Less likely to help
Patients who are already living with HIV or those who do not have risk factors for HIV infection may not benefit from this research.
What this research studies
This research focuses on creating a vaccine that targets the mucosal surfaces where HIV typically enters the body. By stimulating the immune system at these entry points, the goal is to enhance the body's ability to block or contain the virus before it can spread. The approach involves delivering viral antigens to mucosal tissues over time, which may help maintain a heightened immune response. This innovative strategy aims to provide both immediate and long-term protection against HIV infection.
Why it matters
Potential benefit: If successful, this research could lead to a more effective vaccine that significantly reduces the risk of HIV infection.
How similar studies have gone: While there have been many attempts at HIV vaccines, this approach is novel and aims to address specific barriers that previous vaccines have not successfully tackled.
Where this research is happening
-
Texas Biomedical Research Institute
San Antonio, United States Active
Researchers
- Principal investigator: Gauduin, Marie-Claire Elisabeth — Texas Biomedical Research Institute
- Study coordinator: Gauduin, Marie-Claire Elisabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.