Understanding how to better control tuberculosis in the lungs before it forms granulomas
Official title: Mechanisms of efficient control of Mycobacterium tuberculosis in the lungs prior to granuloma
Funded at Texas Biomedical Research Institute · NIH-11135548 · Data updated 2026-11-12
This study is looking at new ways to create a better vaccine for tuberculosis (TB) that could help your body fight the disease more effectively, using a modified version of the bacteria that causes TB to boost your immune response.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Biomedical Research Institute NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | July 9, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $1,231,164 |
| NIH project number | 5R01AI184623-02 |
| Project ID | NIH-11135548 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of tuberculosis infection or those who have been exposed to TB.
✕Less likely to help
Patients who are already infected with active tuberculosis or those with severe immune deficiencies may not benefit from this research.
What this research studies
This research investigates new vaccination strategies to improve control of tuberculosis (TB) in the lungs. It focuses on using an attenuated strain of Mycobacterium tuberculosis that expresses protective antigens absent in the current BCG vaccine. By studying immune responses in animal models, the research aims to identify how these new vaccines can generate long-lasting protection against TB. Advanced techniques like single-cell RNA sequencing and imaging will be employed to analyze immune dynamics in the lungs.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that provide better protection against tuberculosis.
How similar studies have gone: Other research has shown promise in using novel vaccination strategies for tuberculosis, indicating potential for success in this approach.
Where this research is happening
-
Texas Biomedical Research Institute
San Antonio, United States Active
Researchers
- Principal investigator: Kaushal, Deepak — Texas Biomedical Research Institute
- Study coordinator: Kaushal, Deepak
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.