Understanding how to better control tuberculosis in the lungs before it forms granulomas
Mechanisms of efficient control of Mycobacterium tuberculosis in the lungs prior to granuloma
['FUNDING_R01'] · TEXAS BIOMEDICAL RESEARCH INSTITUTE · NIH-11135548
This study is looking at new ways to create a better vaccine for tuberculosis (TB) that could help your body fight the disease more effectively, using a modified version of the bacteria that causes TB to boost your immune response.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS BIOMEDICAL RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-11135548 on ClinicalTrials.gov |
What this research studies
This research investigates new vaccination strategies to improve control of tuberculosis (TB) in the lungs. It focuses on using an attenuated strain of Mycobacterium tuberculosis that expresses protective antigens absent in the current BCG vaccine. By studying immune responses in animal models, the research aims to identify how these new vaccines can generate long-lasting protection against TB. Advanced techniques like single-cell RNA sequencing and imaging will be employed to analyze immune dynamics in the lungs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of tuberculosis infection or those who have been exposed to TB.
Not a fit: Patients who are already infected with active tuberculosis or those with severe immune deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that provide better protection against tuberculosis.
How similar studies have performed: Other research has shown promise in using novel vaccination strategies for tuberculosis, indicating potential for success in this approach.
Where this research is happening
SAN ANTONIO, UNITED STATES
- TEXAS BIOMEDICAL RESEARCH INSTITUTE — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAUSHAL, DEEPAK — TEXAS BIOMEDICAL RESEARCH INSTITUTE
- Study coordinator: KAUSHAL, DEEPAK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus