Improving immune responses to tuberculosis in people with HIV
Official title: Modulating Indoleamines to Optimize Immunity in the Setting of Mtb/HIV Co-infection
Funded at Texas Biomedical Research Institute · NIH-11123498 · Data updated 2026-11-12
This study is looking at how changing certain immune pathways might help people with both tuberculosis (TB) and HIV fight these infections better, using macaque models to find new ways to improve treatment for patients dealing with both conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Biomedical Research Institute NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | June 21, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $905,874 |
| NIH project number | 5R01AI181701-02 |
| Project ID | NIH-11123498 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are co-infected with HIV and tuberculosis.
✕Less likely to help
Patients who are solely infected with HIV or TB without co-infection may not benefit from this research.
What this research studies
This research investigates how modulating specific immune pathways can enhance the body's ability to fight tuberculosis (TB) in individuals co-infected with HIV. Using macaque models, the study examines the effects of blocking a pathway involving indole 2,3-dioxygenase (IDO) on immune responses to TB and HIV. By understanding these mechanisms, the research aims to identify new strategies that could improve treatment outcomes for patients with both infections. The findings could lead to better therapeutic approaches that enhance immunity and reduce the incidence of TB in HIV-infected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that significantly reduce the risk of tuberculosis in people living with HIV.
How similar studies have gone: Previous research has shown promise in similar approaches targeting immune modulation to improve outcomes in co-infected individuals, suggesting potential for success in this study.
Where this research is happening
-
Texas Biomedical Research Institute
San Antonio, United States Active
Researchers
- Principal investigator: Mehra, Smriti — Texas Biomedical Research Institute
- Study coordinator: Mehra, Smriti
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.