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Clinical trials and research at Spaulding Rehabilitation Hospital
As of November 12, 2026, Find a Trial lists 18 clinical trials run by Spaulding Rehabilitation Hospital that are recruiting, in United States. By phase: Early Phase 1 (2), Phase 2 (1). There are also 35 NIH-funded research projects at this institution, with $14.4 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 18Clinical trials
- 35NIH research projects
- 1Country
Newest trials
All recruiting trials (18)
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Relying on a pill combo to boost arm movement gains after stroke
This study tests whether adding Telmisartan, Cilostazol, and Metformin to robot-assisted arm and hand therapy helps stroke survivors improve movement more than therapy alone.
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Comparing brain-to-brain signals in couples and strangers using EEG
Researchers will see if EEG-recorded brain-to-brain signals differ when healthy adults interact with their romantic partner versus a stranger, both in person and remotely.
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Wrist-worn device to encourage use of the weaker arm after a recent stroke
This trial tests whether a wrist-worn sensor system plus motor and behavioral home coaching helps people 1–6 months after a stroke with moderate arm weakness use their affected arm more than a usual home-exercise program.
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Wearable sensors and a smartphone app to help you use your affected arm at home.
This trial tests whether a smartphone app that visualizes data from wrist and finger wearables helps people more than 12 months after stroke use their affected arm more during daily activities.
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Treatment for knee osteoarthritis using shockwave therapy
This study is testing if shockwave therapy can help people with knee osteoarthritis after ACL surgery feel less pain and move better compared to those who receive a fake treatment.
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Low-oxygen sessions and noninvasive spinal stimulation to improve walking after spinal cord injury.
This study tries short, repeated bouts of mild low oxygen together with noninvasive spinal cord stimulation and walking practice to help adults with chronic spinal cord injury walk better and build leg strength.
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Ujjayi yogic breathing to improve heart‑lung synchrony after spinal cord injury
This trial will try regular Ujjayi yogic breathing with adults 18–60 who have spinal cord injuries to see if it improves breathing patterns, lung function, breathing control, and sleep.
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Combining gentle ear vagus nerve stimulation with online support to ease functional dyspepsia
This trial will test whether daily mild ear vagus nerve stimulation plus weekly online support sessions can help adults with functional dyspepsia reduce stomach pain and bothersome fullness.
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Cognitive training and acupuncture for fibromyalgia pain relief
This study is testing a new therapy that combines brain training and acupuncture to see if it can help people with fibromyalgia feel less pain by improving the connection between patients and their healthcare providers.
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MDMA-assisted therapy for fibromyalgia
This trial will test whether MDMA-assisted therapy can reduce pain and improve emotional and interpersonal functioning in adults with fibromyalgia.
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Investigating the effects of placebo on stroke recovery
This study is testing how different types of placebo treatments can help people recovering from a stroke feel better and improve their brain function.
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Wrist sensor system to increase use of the weak arm at home after stroke
This program will test whether wearing the StrokeWear wrist sensor combined with a motor and behavioral home program helps chronic stroke survivors with hemiparesis use their affected arm more than a standard home-exercise plan.
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Combining low oxygen therapy and spinal stimulation to improve walking after spinal cord injury
This study is testing if combining low oxygen therapy with spinal stimulation and walking training can help people with chronic spinal cord injuries walk better.
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Home-based treatment for phantom limb pain using brain stimulation and sensory training
This study is testing whether a new home-based treatment combining brain stimulation and sensory training can help people with phantom limb pain feel better compared to their usual care.
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PostureCheck: a camera tool to detect and correct compensatory posture during robot-assisted arm therapy
This will test whether a camera-based PostureCheck system helps stroke survivors with moderate-to-severe arm impairment get better results from robot-assisted arm therapy when used in one-on-one versus small-group sessions.
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Noninvasive brain stimulation for carpal tunnel syndrome treatment
This study is testing if a new noninvasive brain stimulation treatment can help reduce pain for people with Carpal Tunnel Syndrome.
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Home-based retraining of hand function for stroke survivors using a new device
This study is testing a new home device to see if it can help stroke survivors improve their hand function better than traditional therapy.
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Breathing low oxygen to improve movement after spinal injury
This study is testing if breathing low oxygen for short periods can help people with chronic spinal cord injuries improve their movement and walking ability when combined with exercise.
NIH-funded research (35)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Non-invasive brain stimulation to reduce nausea in adults
This NIH-funded project tests whether a gentle, non-invasive brain stimulation method can lessen nausea in adults by affecting the brain networks that process nausea.
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Neurobiological roots of pain catastrophizing in burn survivors and how CBT may change them
We’re looking at how painful burn injuries and the way people think about pain affect one another, and how cognitive-behavioral therapy might change the brain to reduce chronic pain.
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Sex differences in aging knees and osteoarthritis
A study exploring why knee osteoarthritis behaves differently in aging men and women and what biological factors drive these differences.
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Genetic information flow and aging: how genes communicate in muscle tissues
Aims to understand how aging changes the flow of genetic information in muscle cells and test whether changing specific genes can influence aging-related decline.
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CASE: A practical sports test to guide kids back after concussion
A child-focused test called CASE will check how a child recovers after a concussion so doctors can decide when it’s safe to return to sports.
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Sympathetic Activation and Brain Blood Flow After Traumatic Brain Injury
This project looks at how the brain’s blood flow and automatic nervous system activity change after a moderate to severe traumatic brain injury, using noninvasive tests to better predict recovery.
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How exercise changes tiny blood particles to help knee joints
This project explores whether exercise-driven changes in tiny particles in the blood can protect and improve knee cartilage in people with osteoarthritis.
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Vagus nerve stimulation plus cognitive behavioral therapy to ease functional dyspepsia symptoms
This project combines gentle vagus nerve stimulation with cognitive behavioral therapy to help adults with functional dyspepsia reduce stomach pain, fullness, and related anxiety.
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How aging and muscle activity change tiny particles that help muscles heal
This project tests whether small particles released by muscle cells and the stiffness of the surrounding tissue affect how well older muscles recover after injury.
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Home brain stimulation plus guided touch for phantom limb pain
This project sees if a portable brain stimulation device combined with guided touch exercises can lower phantom limb pain for people who have lost a limb.
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Perspective-taking training to strengthen the patient–clinician connection
This work teaches people with fibromyalgia skills to better take another person's perspective to strengthen brain-to-brain connections with their clinician and help reduce pain during acupuncture.
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Training to improve understanding between patients and clinicians to enhance pain relief
This study is looking at how teaching chronic pain patients to better understand their own and their doctors' feelings can help them connect more effectively, which might lead to better pain relief, especially with acupuncture.
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Why Knee Arthritis Affects Men and Women Differently with Age
This research explores why knee arthritis often affects older women more severely than men, looking at genetic and hormonal factors.
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How aging and muscle activity affect muscle healing
This study is looking at how getting older and how our muscles work can affect the way muscle stem cells help heal injuries, with the goal of finding better ways to help older adults recover their muscle strength and health.
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How different body areas affect the brain-gut connection in people with indigestion
This research explores how stimulating specific body points might improve digestion and brain-gut communication for people experiencing chronic indigestion.
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Improving care for people with aphasia after stroke
This study is all about finding better ways to help people with aphasia, a condition that makes it hard to communicate after a stroke, by improving the support they get from healthcare providers and their families during recovery.
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Exploring the effects of vagal stimulation and therapy on gut-brain interactions in functional dyspepsia
This study is looking at whether using a device that stimulates the vagus nerve along with talking therapy can help people with functional dyspepsia feel better and improve their quality of life.
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How exercise affects knee joint health through tiny particles in the blood
This study looks at how exercise can help improve knee health for people with knee osteoarthritis by examining tiny particles in the body that might play a role in keeping the cartilage healthy.
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Understanding how genes contribute to the aging process
This project explores how genetic information changes over time in our cells, which helps us understand why our bodies age.
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Using a special scaffold to help heal severe muscle injuries
This study is testing a new biodegradable support that helps heal muscle damage for people with volumetric muscle loss by encouraging the body to repair itself, which could lead to better muscle function and an improved quality of life.
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Training to improve understanding between patients and clinicians for better pain management
This study is looking at how teaching people with fibromyalgia to better understand and connect with their doctors can improve their pain management, especially when using acupuncture.
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Investigating how placebo effects can aid recovery in stroke patients
This study is looking at how the brain responds to different treatments, including a special kind of placebo, to help older adults recovering from strokes, with the hope of finding better ways to support their healing process.
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Reducing opioid use in patients undergoing rehabilitation for pain management
This study is looking for ways to help people in rehab manage their pain better without relying too much on opioids, using a new technique that combines the power of the mind and medicine, and it’s designed for anyone who’s going through intensive rehabilitation.
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Investigating how different acupuncture points affect the gut-brain connection in functional dyspepsia.
This study is looking at how acupuncture might help people with functional dyspepsia by seeing how it affects the brain and stomach, using special imaging techniques to track any changes during treatment.
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Understanding how brain activity affects chronic pain management through therapy
This study is exploring how people with chronic pain, like fibromyalgia, can learn to control their brain activity to better manage their pain, and it’s designed for those looking for new ways to improve their treatment through techniques like cognitive behavioral therapy.
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Exploring innovative rehabilitation techniques for improved patient outcomes
This study is exploring new ways to help people recover from different health conditions, and it invites patients to share their experiences and feedback to improve rehabilitation methods.
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Exploring innovative rehabilitation techniques for improved patient outcomes
This study is exploring new ways to help people recover better from different health conditions by using personalized rehab programs that fit their unique needs, and it’s open to patients who want to improve their abilities over the next three years.
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Exploring innovative rehabilitation techniques for patients.
This study is exploring new ways to help people recover better from different health conditions by trying out personalized therapies that could boost their physical abilities and overall well-being.
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Exploring innovative rehabilitation techniques for improved patient outcomes
This study is exploring new ways to help people recover better from different health conditions by trying out special rehab programs that are made just for them, so they can feel better and enjoy life more.
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Improving rehabilitation services for patients with disabilities
This study is all about finding new and better ways to help people with disabilities during their rehabilitation, and we want to hear from patients like you to make sure these new methods really work!
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Exploring ways to repair and regenerate damaged tissues and organs.
This study is exploring new ways to help heal damaged tissues and organs by using special treatments that involve movement, heat, and electricity, so that patients can recover better and enjoy a higher quality of life.
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Understanding how the brain and gut communicate without invasive procedures
This study is looking at how your brain and gut communicate with each other and how that affects your digestion, using safe techniques like MRI scans while you eat, to help us learn more about gut health.
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Exploring new therapies for managing chronic pain through advanced analysis methods
This study is exploring new ways to help people with chronic pain by using special therapies that change how the brain processes pain, and it's designed for those who haven't found relief with regular pain medications.
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How critical care affects cognitive and mental health in older adults
This study is looking at how being in the ICU affects the thinking and mental health of older adults over 60, especially those who might develop issues like Alzheimer's, and it aims to find new ways to spot these problems early so we can help them feel better.
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Using brain stimulation and exercise to manage fibromyalgia pain
This study is exploring a new way to help people with fibromyalgia feel less pain by using a gentle brain stimulation technique along with aerobic exercise, hoping to improve their overall comfort and quality of life.
Quick answers
How many clinical trials run by Spaulding Rehabilitation Hospital are recruiting right now?
18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
All of them have sites in United States. Each study page lists its sites and which ones are recruiting.
What phases are they in?
Early Phase 1: 2, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.