Genetic information flow and aging: how genes communicate in muscle tissues
Official title: Genetic information flow in the Hallmarks of Aging: from system-level analytics to mechanistic interventions
Funded at Spaulding Rehabilitation Hospital · NIH-11370551 · Data updated 2026-11-12
Aims to understand how aging changes the flow of genetic information in muscle cells and test whether changing specific genes can influence aging-related decline.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Spaulding Rehabilitation Hospital NIH-funded |
| Lab location | 1 site (Charlestown, United States) |
| Project start | September 20, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $432,083 |
| NIH project number | 5R01AG082739-04 |
| Project ID | NIH-11370551 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals researching aging or with a condition affecting muscle aging who could benefit from future gene-targeted approaches.
✕Less likely to help
People looking for immediate clinical results or non-muscle aging studies may not directly benefit.
What this research studies
This project looks at aging as a system-wide change in how cells talk to each other, focusing on muscle cells in mice. It combines single-cell RNA data, mathematical analysis, and targeted genetic tweaks to see how information transfer among genes shifts with age and sex. The researchers will test whether reducing or boosting certain genes can alter aging-related information flow and muscle function, using real-time functional assessments in mice. The work blends big-data analysis with lab experiments to connect molecular changes to physical muscle performance.
Why it matters
Potential benefit: If successful, it could identify gene targets to preserve muscle function during aging and guide future therapies.
How similar studies have gone: Prior work shows that gene networks influence aging markers; this study adds a mechanistic, sex-specific angle in muscle tissue.
Where this research is happening
-
Spaulding Rehabilitation Hospital
Charlestown, United States Active
Researchers
- Principal investigator: Ambrosio, Fabrisia — Spaulding Rehabilitation Hospital
- Study coordinator: Ambrosio, Fabrisia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.