Understanding how genes contribute to the aging process
Genetic information flow in the Hallmarks of Aging: from system-level analytics to mechanistic interventions
['FUNDING_R01'] · SPAULDING REHABILITATION HOSPITAL · NIH-11085147
This project explores how genetic information changes over time in our cells, which helps us understand why our bodies age.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SPAULDING REHABILITATION HOSPITAL (nih funded) |
| Locations | 1 site (CHARLESTOWN, UNITED STATES) |
| Trial ID | NIH-11085147 on ClinicalTrials.gov |
What this research studies
Our bodies age due to a system-wide decline in how cells and tissues work, linked to specific 'hallmarks' of aging. This project aims to uncover how these hallmarks interact and which genes are key drivers of aging, as their relationships are not fully understood. We will look at how genetic information flow changes in muscle cells of mice as they age, using advanced computational tools and genetic methods. The goal is to map the timeline and importance of these genetic changes and confirm their effects on muscle function.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients, but future studies building on this work may seek individuals interested in healthy aging or age-related muscle conditions.
Not a fit: Patients seeking immediate treatment or direct clinical intervention for existing conditions would not directly benefit from this early-stage mechanistic research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to intervene and slow down or prevent age-related decline in cell and tissue function.
How similar studies have performed: While the concept of aging hallmarks is established, this project's approach to mapping genetic information flow across these hallmarks is novel and builds on previous work showing information loss in aging networks.
Where this research is happening
CHARLESTOWN, UNITED STATES
- SPAULDING REHABILITATION HOSPITAL — CHARLESTOWN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AMBROSIO, FABRISIA — SPAULDING REHABILITATION HOSPITAL
- Study coordinator: AMBROSIO, FABRISIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.