Understanding how genes contribute to the aging process
Official title: Genetic information flow in the Hallmarks of Aging: from system-level analytics to mechanistic interventions
Funded at Spaulding Rehabilitation Hospital · NIH-11085147 · Data updated 2026-11-12
This project explores how genetic information changes over time in our cells, which helps us understand why our bodies age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Spaulding Rehabilitation Hospital NIH-funded |
| Lab location | 1 site (Charlestown, United States) |
| Project start | September 20, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $424,986 |
| NIH project number | 5R01AG082739-03 |
| Project ID | NIH-11085147 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is not directly recruiting patients, but future studies building on this work may seek individuals interested in healthy aging or age-related muscle conditions.
✕Less likely to help
Patients seeking immediate treatment or direct clinical intervention for existing conditions would not directly benefit from this early-stage mechanistic research.
What this research studies
Our bodies age due to a system-wide decline in how cells and tissues work, linked to specific 'hallmarks' of aging. This project aims to uncover how these hallmarks interact and which genes are key drivers of aging, as their relationships are not fully understood. We will look at how genetic information flow changes in muscle cells of mice as they age, using advanced computational tools and genetic methods. The goal is to map the timeline and importance of these genetic changes and confirm their effects on muscle function.
Why it matters
Potential benefit: If successful, this work could lead to new ways to intervene and slow down or prevent age-related decline in cell and tissue function.
How similar studies have gone: While the concept of aging hallmarks is established, this project's approach to mapping genetic information flow across these hallmarks is novel and builds on previous work showing information loss in aging networks.
Where this research is happening
-
Spaulding Rehabilitation Hospital
Charlestown, United States Active
Researchers
- Principal investigator: Ambrosio, Fabrisia — Spaulding Rehabilitation Hospital
- Study coordinator: Ambrosio, Fabrisia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.