Exploring the effects of vagal stimulation and therapy on gut-brain interactions in functional dyspepsia
Synergistic gut-brain axis modulation via vagal stimulation and cognitive behavioral therapy in functional dyspepsia
This study is looking at whether using a device that stimulates the vagus nerve along with talking therapy can help people with functional dyspepsia feel better and improve their quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Spaulding Rehabilitation Hospital NIH-funded |
| Lab location | 1 site (Charlestown, United States) |
| Project ID | NIH-11095974 on NIH RePORTER |
What this research studies
This research investigates how combining vagal nerve stimulation with cognitive behavioral therapy can improve symptoms of functional dyspepsia, a condition causing recurrent stomach discomfort without a clear cause. The study aims to understand the interaction between these two treatment modalities, targeting both the gut and brain to enhance patient outcomes. By employing a randomized approach, the research will assess the effectiveness of this multimodal strategy in alleviating symptoms and improving quality of life for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who experience symptoms of functional dyspepsia and have not found relief from standard treatments.
Not a fit: Patients with functional dyspepsia who have already responded well to existing pharmacological treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for patients with functional dyspepsia who have not responded to traditional therapies.
How similar studies have performed: Previous research has shown promise in using combined therapeutic approaches for gut-brain disorders, indicating potential for success in this novel integration.
Where this research is happening
Charlestown, United States
- Spaulding Rehabilitation Hospital — Charlestown, United States (Active)
Researchers
- Principal investigator: Sclocco, Roberta — Spaulding Rehabilitation Hospital
- Study coordinator: Sclocco, Roberta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.