Sponsor or institution
Clinical trials and research at San Diego Biomedical Research Institute
As of November 12, 2026, Find a Trial lists 30 NIH-funded research projects at this institution, with $17.2 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 30NIH research projects
NIH-funded research (30)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Immunize to Build Broad HIV Antibodies
A HIV vaccine grant tests new lab-made proteins and vaccines designed to help the immune system produce broadly protective antibodies for people at risk of HIV.
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How cancer-linked pathways create fragile spots in DNA
This project looks at how cancer-related cellular pathways make weak spots in chromosomes so patterns in a tumor's genome can point to the pathways driving that cancer.
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Cis-acting elements that control when DNA replication starts in development
Researchers are studying specific DNA sequences that help determine when and how quickly DNA replication happens in early cell development, with potential implications for cancer.
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Nanoscale imaging of HIV Env complexes to improve NK cell antibody therapies
A study to better understand how HIV envelope immune complexes affect natural killer cell antibody therapies and how to design better antibodies.
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Meth and HIV in the brain: how meth use may affect HIV latency and brain cells
A study to understand how methamphetamine use might change HIV behavior in brain cells and how that could influence HIV persistence and brain health in people living with HIV.
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Role of a special interferon-responsive T cell in allergies and asthma
A study explores a unique interferon-responsive T cell type that may influence allergies and asthma, aiming to understand why some people become allergic and how this T cell subset could affect airway inflammation.
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How methamphetamine affects HIV in the brain
This project looks at how methamphetamine changes where HIV hides and stays active in brain cells of people with HIV to help explain lasting brain problems.
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How cannabinoids affect the brain’s protective barrier in people with HIV
This project studies how cannabis compounds influence the brain’s protective barrier in people living with HIV.
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Noncanonical autophagy activators to help dementia patients
A new NIH project searches for safer, more precise ways to boost the brain’s cleanup systems to help people with Alzheimer’s and related dementias.
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Hypoxia-mimicking therapy to help recovery in inflammatory demyelinating disease
Aims to see if drugs that mimic low-oxygen signals can speed recovery and reduce disability in conditions like multiple sclerosis by strengthening blood vessels and helping immune cells leave the brain.
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Targeting IL-13Rα1 signaling to slow neurodegeneration in Parkinson’s-related disease
Researchers are studying whether blocking a specific inflammatory signal in brain cells can protect dopamine neurons and slow neurodegeneration in conditions like Parkinson’s disease.
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How cancer-driven pathways create weak spots in chromosomes
This project looks at whether cancer-related cell pathways cause fragile spots in chromosomes that lead to DNA breaks in tumors, aiming to help people with different cancers.
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The effects of calorie restriction on autoimmunity and body temperature regulation
This study is looking at how eating fewer calories might help people with lupus age healthier and possibly reduce their symptoms, by checking how it affects body temperature during sleep and the genes in their tissues.
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Cannabis and the Brain's Protective Barrier in HIV
This research explores how cannabis might affect the brain's protective barrier in people living with HIV.
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How HIV antibodies and NK cells team up to kill infected cells
Researchers compare how different HIV antibodies guide natural killer (NK) cells to find and kill HIV-infected cells to help people living with HIV.
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A newly discovered interferon-responsive immune cell linked to allergies and asthma
Researchers are looking at whether a newly discovered interferon-responsive T cell helps protect people exposed to allergens from developing allergic reactions and asthma.
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Understanding how oxygen-like treatments can help with multiple sclerosis
This research explores how new medications that mimic low-oxygen conditions might help people recover from multiple sclerosis by protecting the brain.
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Investigating a new type of T cell involved in allergy and asthma
This study is looking at a special type of immune cell that reacts to allergens to better understand how they affect asthma and allergies, and it's for anyone interested in learning more about how these cells might help us find new ways to treat allergic reactions.
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Investigating a new type of immune cell that may protect against allergies
This study is looking at a special type of immune cell that might help protect against allergies and asthma, and it's for anyone interested in how our bodies respond to things like dust mites; researchers want to see how these cells behave differently in people with and without allergies to find new ways to prevent and
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Understanding Inflammation in Brain Cell Loss
This research explores how certain immune signals in the brain might contribute to the loss of brain cells in conditions like Parkinson's disease.
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Understanding how cancer pathways cause genome instability
This study is looking at how certain cancer pathways can cause problems with our genes, which might help doctors understand your cancer better and find the best treatment for you.
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How microglia help protect the brain's blood vessels during low oxygen levels
This study is looking at how certain brain cells help protect blood vessels during times when there isn't enough oxygen, especially in older adults, to see if this can help prevent memory problems and keep the brain healthy as we age.
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Investigating how anti-inflammatory signals affect neurodegeneration in Alzheimer's disease
This study is looking at how certain immune signals might help protect brain cells in people with Alzheimer's disease, and it hopes to find new ways to slow down the disease by focusing on these signals.
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Exploring how hypoxia mimetics can help treat inflammatory demyelinating diseases like multiple sclerosis
This study is looking at how certain medications that act like low oxygen can help people with multiple sclerosis recover better by protecting the brain's barrier and helping clear out harmful immune cells.
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The effects of methamphetamine on HIV in the brain
This study is looking at how methamphetamine affects the way HIV hides in brain cells, especially in immune cells called microglia, to help find better treatment options for people living with HIV.
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Investigating how inflammatory signals affect nerve cell survival in neurodegenerative diseases
This study is looking at how certain signals in the brain might affect the survival of nerve cells in people with Parkinson's disease, with the hope of finding new ways to protect these important cells and slow down the disease.
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Investigating how calorie restriction and body temperature affect Alzheimer's disease
This study is looking at how eating fewer calories might help people with Alzheimer's by seeing if lowering body temperature can ease symptoms and boost brain health.
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Investigating how HIV antibodies interact with immune cells to enhance their effectiveness.
This study is looking at how the shape of HIV antibodies can help boost the body's natural killer cells, which play an important role in fighting HIV, with the hope of creating better treatments and vaccines for HIV and other diseases.
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Investigating how silica exposure and viral infections contribute to autoimmune diseases
This study is looking at how exposure to silica and viruses, along with genetic factors, might work together to trigger lupus, an autoimmune disease, and it’s using mice to see if these combined exposures lead to stronger immune responses than just one alone.
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Investigating how certain proteins affect immune responses in lupus
This study is looking at how two proteins, TASL and SLC15A4, affect the immune system in people with lupus, and it hopes to find out if blocking SLC15A4 could help treat lupus.
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