Understanding how cancer pathways cause genome instability
Official title: Oncogenic pathway-induced fragile sites: a new paradigm for understanding genome instability in cancer
Funded at San Diego Biomedical Research Institute · NIH-11046530 · Data updated 2026-11-12
This study is looking at how certain cancer pathways can cause problems with our genes, which might help doctors understand your cancer better and find the best treatment for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego Biomedical Research Institute NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | March 10, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $467,713 |
| NIH project number | 5R01CA270335-04 |
| Project ID | NIH-11046530 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with various types of cancer who are seeking personalized treatment options based on their genetic makeup.
✕Less likely to help
Patients with non-cancerous conditions or those whose cancers do not exhibit significant genomic instability may not benefit from this research.
What this research studies
This research investigates the mechanisms behind genome instability in cancer by analyzing how certain cancer pathways lead to chromosome breaks and gaps. Using advanced techniques like whole genome sequencing, the study aims to identify specific patterns of genetic disruptions that can inform cancer diagnosis and treatment. By culturing cells in a way that mimics cancer conditions, researchers hope to uncover the underlying causes of these genetic changes and their implications for therapy. The ultimate goal is to develop predictive models that can guide treatment decisions based on the unique genetic profile of a patient's cancer.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments by identifying specific genetic disruptions in tumors.
How similar studies have gone: Previous research has shown promise in using genomic sequencing to identify treatment targets in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
San Diego Biomedical Research Institute
San Diego, United States Active
Researchers
- Principal investigator: Gilbert, David M — San Diego Biomedical Research Institute
- Study coordinator: Gilbert, David M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.