Understanding how cancer pathways cause genome instability
Oncogenic pathway-induced fragile sites: a new paradigm for understanding genome instability in cancer
['FUNDING_R01'] · SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE · NIH-11046530
This study is looking at how certain cancer pathways can cause problems with our genes, which might help doctors understand your cancer better and find the best treatment for you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (SAN DIEGO, UNITED STATES) |
| Trial ID | NIH-11046530 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind genome instability in cancer by analyzing how certain cancer pathways lead to chromosome breaks and gaps. Using advanced techniques like whole genome sequencing, the study aims to identify specific patterns of genetic disruptions that can inform cancer diagnosis and treatment. By culturing cells in a way that mimics cancer conditions, researchers hope to uncover the underlying causes of these genetic changes and their implications for therapy. The ultimate goal is to develop predictive models that can guide treatment decisions based on the unique genetic profile of a patient's cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with various types of cancer who are seeking personalized treatment options based on their genetic makeup.
Not a fit: Patients with non-cancerous conditions or those whose cancers do not exhibit significant genomic instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cancer treatments by identifying specific genetic disruptions in tumors.
How similar studies have performed: Previous research has shown promise in using genomic sequencing to identify treatment targets in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN DIEGO, UNITED STATES
- SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE — SAN DIEGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GILBERT, DAVID M — SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE
- Study coordinator: GILBERT, DAVID M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer research, anti-cancer therapy, Cancer Biology, cancer diagnosis, Cancer Genes