Investigating a new type of T cell involved in allergy and asthma
Official title: Role of a Novel Interferon Responsive T Cell Subset in Allergy and Asthma
Funded at San Diego Biomedical Research Institute · NIH-11138363 · Data updated 2026-11-12
This study is looking at a special type of immune cell that reacts to allergens to better understand how they affect asthma and allergies, and it's for anyone interested in learning more about how these cells might help us find new ways to treat allergic reactions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego Biomedical Research Institute NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | September 20, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $487,917 |
| NIH project number | 7R01AI163665-03 |
| Project ID | NIH-11138363 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with asthma or allergies, particularly those reacting to common allergens like house dust mites.
✕Less likely to help
Patients who do not have asthma or allergies may not benefit from this research.
What this research studies
This research focuses on understanding a novel subset of T cells that respond to allergens, particularly in the context of asthma and allergies. By analyzing the genetic profiles of T cells from individuals with and without allergies, the researchers aim to uncover how these cells contribute to airway inflammation. The study involves examining a large number of allergen-reactive T cells to identify differences in their behavior and characteristics, which could lead to new insights into allergy mechanisms and potential treatments.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing allergies and asthma.
How similar studies have gone: Other research has shown promise in understanding T cell responses in allergies, but the specific focus on this novel T cell subset is relatively new and untested.
Where this research is happening
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San Diego Biomedical Research Institute
San Diego, United States Active
Researchers
- Principal investigator: Seumois, Gregory — San Diego Biomedical Research Institute
- Study coordinator: Seumois, Gregory
Related research
Other NIH-funded projects on the same topics.
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Childhood Allergy and the Neonatal Environment: Early Life Airways and Asthma
A long-term study following newborns to age 5 to understand how early-life nose and airway biology, immune development, and the environment influence asthma risk.
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Role of a special interferon-responsive T cell in allergies and asthma
A study explores a unique interferon-responsive T cell type that may influence allergies and asthma, aiming to understand why some people become allergic and how this T cell subset could affect airway inflammation.
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Children's Allergy and Asthma Data Hub
A national data hub will pool and harmonize child allergy and asthma cohort data to help researchers discover ways to prevent asthma in kids.
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Viral and Host Factors in Infant and Child Allergy and Asthma
This grant explores why some babies and young children develop asthma by studying how viruses, environment, and airway cells interact from birth.
-
Children's Allergy and Asthma Data Hub (CADRE)
This project builds a shared data hub that combines many childhood allergy and asthma birth-study records so researchers can find early-life factors that change a child's risk of asthma.
-
How microRNAs control allergy and asthma
This work looks at tiny gene-regulating molecules called microRNAs to find molecular ways to reduce allergic inflammation in people with asthma.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.