Investigating how inflammatory signals affect nerve cell survival in neurodegenerative diseases
Official title: Anti-inflammatory signals and neurodegeneration
Funded at San Diego Biomedical Research Institute · NIH-10928425 · Data updated 2026-11-12
This study is looking at how certain signals in the brain might affect the survival of nerve cells in people with Parkinson's disease, with the hope of finding new ways to protect these important cells and slow down the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego Biomedical Research Institute NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | September 21, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $646,104 |
| NIH project number | 1R56NS134632-01 |
| Project ID | NIH-10928425 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's disease or those at risk of developing neurodegenerative conditions.
✕Less likely to help
Patients with neurodegenerative diseases not related to inflammation or those without a diagnosis of Parkinson's disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific inflammatory signals in the survival of nerve cells, particularly in the context of neurodegenerative diseases like Parkinson's disease. The study examines how the activation of certain receptors in the brain can lead to the death of dopamine-producing neurons, which are crucial for movement and coordination. By using a mouse model, the researchers aim to explore the mechanisms behind this cell death and how it relates to inflammation and oxidative stress. The ultimate goal is to identify potential therapeutic targets that could help slow down neurodegeneration in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow the progression of neurodegenerative diseases like Parkinson's.
How similar studies have gone: Previous research has shown promising results in targeting inflammatory pathways to protect nerve cells, suggesting that this approach could be effective.
Where this research is happening
-
San Diego Biomedical Research Institute
San Diego, United States Active
Researchers
- Principal investigator: Conti, Bruno — San Diego Biomedical Research Institute
- Study coordinator: Conti, Bruno
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.