Investigating how calorie restriction and body temperature affect Alzheimer's disease
Official title: Calorie Restriction, Body Temperature and Alzheimers Disease
Funded at San Diego Biomedical Research Institute · NIH-10909300 · Data updated 2026-11-12
This study is looking at how eating fewer calories might help people with Alzheimer's by seeing if lowering body temperature can ease symptoms and boost brain health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego Biomedical Research Institute NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $243,750 |
| NIH project number | 5R21AG083640-02 |
| Project ID | NIH-10909300 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease, particularly those interested in dietary interventions.
✕Less likely to help
Patients with advanced Alzheimer's disease or those unable to adhere to dietary restrictions may not benefit from this research.
What this research studies
This research explores the effects of calorie restriction (CR) on Alzheimer's disease by examining how reducing body temperature may alleviate symptoms and improve brain health. The study will utilize a well-established animal model of Alzheimer's to test the hypothesis that lower body temperatures can reduce the harmful effects of proteins associated with the disease. By understanding the mechanisms behind CR and temperature regulation, the research aims to uncover potential therapeutic strategies for Alzheimer's patients.
Why it matters
Potential benefit: If successful, this research could lead to new dietary and lifestyle recommendations that may help slow the progression of Alzheimer's disease.
How similar studies have gone: Previous studies have shown promising results regarding calorie restriction and its effects on aging and neurodegenerative diseases, suggesting that this approach may yield beneficial outcomes.
Where this research is happening
-
San Diego Biomedical Research Institute
San Diego, United States Active
Researchers
- Principal investigator: Conti, Bruno — San Diego Biomedical Research Institute
- Study coordinator: Conti, Bruno
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.