Investigating how anti-inflammatory signals affect neurodegeneration in Alzheimer's disease
Official title: Anti-inflammatory signals and neurodegeneration
Funded at San Diego Biomedical Research Institute · NIH-10973850 · Data updated 2026-11-12
This study is looking at how certain immune signals might help protect brain cells in people with Alzheimer's disease, and it hopes to find new ways to slow down the disease by focusing on these signals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego Biomedical Research Institute NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $741,976 |
| NIH project number | 1R01NS134632-01A1 |
| Project ID | NIH-10973850 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurodegenerative conditions.
✕Less likely to help
Patients with neurodegenerative diseases not related to Alzheimer's or those without any cognitive impairment may not benefit from this research.
What this research studies
This research explores the role of specific immune signals in the survival of neurons affected by Alzheimer's disease. It focuses on the interleukin-13 receptor and its impact on neuronal health, particularly in the context of neuroinflammation and oxidative stress. By studying these mechanisms in a mouse model, the research aims to uncover how these signals contribute to neurodegeneration and whether targeting them could slow down the disease process. Patients may benefit from insights that could lead to new therapeutic strategies for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow the progression of Alzheimer's disease.
How similar studies have gone: Other research has shown promise in targeting neuroinflammatory pathways for neurodegenerative diseases, suggesting potential for success in this approach.
Where this research is happening
-
San Diego Biomedical Research Institute
San Diego, United States Active
Researchers
- Principal investigator: Conti, Bruno — San Diego Biomedical Research Institute
- Study coordinator: Conti, Bruno
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.