Exploring how hypoxia mimetics can help treat inflammatory demyelinating diseases like multiple sclerosis
Official title: Evaluating the therapeutic potential of hypoxia mimetics in inflammatory demyelinating disease
Funded at San Diego Biomedical Research Institute · NIH-10946005 · Data updated 2026-11-12
This study is looking at how certain medications that act like low oxygen can help people with multiple sclerosis recover better by protecting the brain's barrier and helping clear out harmful immune cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego Biomedical Research Institute NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | August 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $647,782 |
| NIH project number | 1R01NS138923-01 |
| Project ID | NIH-10946005 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with multiple sclerosis or other inflammatory demyelinating diseases.
✕Less likely to help
Patients with non-inflammatory neurological disorders or those not diagnosed with demyelinating diseases may not benefit from this research.
What this research studies
This research investigates the use of hypoxia mimetics, which are drugs that mimic low oxygen conditions, to improve recovery in patients with inflammatory demyelinating diseases such as multiple sclerosis (MS). The study focuses on how these drugs can enhance the integrity of the blood-brain barrier and promote the removal of harmful immune cells from the central nervous system. By optimizing treatment protocols and understanding the underlying mechanisms, the research aims to provide new therapeutic options for patients suffering from MS and similar conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and reduced disability for patients with multiple sclerosis.
How similar studies have gone: Previous research has shown promising results with hypoxia mimetics in animal models, indicating potential for success in human applications.
Where this research is happening
-
San Diego Biomedical Research Institute
San Diego, United States Active
Researchers
- Principal investigator: Milner, D. Richard — San Diego Biomedical Research Institute
- Study coordinator: Milner, D. Richard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.