Investigating how HIV antibodies interact with immune cells to enhance their effectiveness.
Official title: HIV antibodies and NK cell ADCC: nanometer-scale tracking of immune synapse dynamics.
Funded at San Diego Biomedical Research Institute · NIH-10894890 · Data updated 2026-11-12
This study is looking at how the shape of HIV antibodies can help boost the body's natural killer cells, which play an important role in fighting HIV, with the hope of creating better treatments and vaccines for HIV and other diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego Biomedical Research Institute NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | September 17, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $492,820 |
| NIH project number | 5R01AI167646-05 |
| Project ID | NIH-10894890 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are interested in new therapeutic approaches.
✕Less likely to help
Patients who are not infected with HIV or those who do not respond to antibody therapies may not benefit from this research.
What this research studies
This research focuses on understanding how the shape and structure of HIV antibodies influence their ability to activate natural killer (NK) cells, which are crucial for fighting HIV infections. By using advanced microscopy techniques, the study aims to track the interactions between antibodies and NK cells at a nanometer scale, providing insights into how these immune responses can be optimized. The ultimate goal is to develop improved antibodies, drugs, and vaccines that can better recruit immune functions to combat HIV and potentially other diseases.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and vaccines for HIV, improving patient outcomes.
How similar studies have gone: Previous research has shown promise in understanding antibody interactions with immune cells, suggesting that this approach could yield valuable insights.
Where this research is happening
-
San Diego Biomedical Research Institute
San Diego, United States Active
Researchers
- Principal investigator: Murin, Charles Daniel — San Diego Biomedical Research Institute
- Study coordinator: Murin, Charles Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.