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Clinical trials and research at H. Lee Moffitt Cancer Center and Research Institute
As of November 12, 2026, Find a Trial lists 70 clinical trials run by H. Lee Moffitt Cancer Center and Research Institute that are recruiting, at sites in 3 countries (most in United States (69), Cambodia (1), Puerto Rico (1)). 1 was first registered in the last 30 days. By phase: Phase 2 (30), Phase 1 (15), Phase 1/2 (4), Early Phase 1 (3). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 70Clinical trials
- 1New in 30 days
- 3Countries
Newest trials
All recruiting trials (70)
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Melanoma treatment with immunotherapy guided by serial ctDNA testing
This trial tests whether regular ctDNA blood tests during treatment can help tailor the plan for patients with advanced melanoma receiving nivolumab and ipilimumab.
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Domatinostat with Sirolimus for relapsed or refractory sarcoma and osteosarcoma
This study tests whether the cancer drugs domatinostat and sirolimus together can help adolescents and adults whose sarcoma or osteosarcoma has come back or stopped responding to standard therapy.
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Dendritic Cell Vaccine with HER2-targeted Therapy or Nivolumab for Breast Cancer with Leptomeningeal Metastasis
This trial tests a dendritic cell vaccine added to trastuzumab for Her2-positive disease or to nivolumab for Her2-negative disease to see if it can be given safely to people with breast cancer that has spread to the leptomeninges.
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See if SAVI Scout MD helps surgeons localize breast cancer more precisely
This study tests whether the SAVI Scout MD radar reflectors help surgeons find and remove breast cancer more accurately, potentially reducing the need for a second operation.
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PIPAC with Mitomycin C for unresectable peritoneal cancer
This phase 1 study tests a breathy, pressurized chemotherapy method (PIPAC-MMC) to see if it is safe and tolerable for adults with unresectable peritoneal carcinomatosis from colorectal, appendiceal, or small bowel cancers.
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High-dose testosterone followed by PSMA-targeted radioligand therapy for metastatic castration-resistant prostate cancer
This trial tests whether short-term high-dose testosterone followed by a PSMA-targeted radioligand (PSMA-617) can help men with metastatic castration-resistant prostate cancer that is progressing on castrate-level testosterone.
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Mindfulness Relapse Prevention for Smoking and Alcohol in Cancer Survivors
This study tests whether Mindfulness-Based Relapse Prevention for Smoking and Alcohol (MBRP-SA) helps cancer survivors quit smoking and reduce risky drinking compared with standard care.
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Brain MRI checks every 6 months for people with stage IV breast cancer
This phase III trial tests whether routine brain MRI every six months helps detect brain metastases earlier in adults with stage IV breast cancer who have no brain symptoms.
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Melphalan liver perfusion followed by tebentafusp for metastatic uveal melanoma
This Phase 2 trial tests whether melphalan delivered to the liver by percutaneous hepatic perfusion followed by tebentafusp helps people with HLA-A*02:01-positive metastatic uveal melanoma confined to the liver.
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Asciminib maintenance after alloHCT or CAR T for adults with Ph+ ALL
Doctors will try asciminib in adults with Ph+ ALL who are in remission after an allogeneic stem cell transplant or CAR T therapy to check safety and find the best dose to help prevent relapse.
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First-in-human testing of FID-022 in solid tumor patients
This project will test an AI tool to spot early cancer-related weight loss and see if diet and exercise support are acceptable for people with newly diagnosed pancreatic cancer.
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Integrating personalized skin cancer risk feedback into community health centers
This project tests whether giving adult patients personalized skin cancer risk information based on genetics and recent sun behaviors increases use of sun-protection and prevention activities at Tampa Family Health Centers.
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Intensive, sequenced chemotherapy for metastatic Ewing sarcoma
This tests an upfront intense 'first strike' followed by sequential 'second strikes' and prolonged maintenance chemotherapy to try to cure people with newly diagnosed widely metastatic Ewing sarcoma or metastatic CIC‑rearranged sarcoma.
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Ropeginterferon treatment for cutaneous T‑cell lymphoma
This trial tests whether ropeginterferon-alfa-2b helps people with cutaneous T‑cell lymphoma who have not responded adequately to multiple prior skin-directed therapies.
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Quality of life and symptom changes over two years in adults with CLL or SLL starting targeted therapy
This study will see how quality of life, fatigue, and symptoms change over two years for adults with CLL or SLL who start treatment with a BTK inhibitor versus a BCL2 inhibitor.
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MIND diet to improve thinking and memory after breast cancer
This trial will try the MIND diet with breast cancer survivors who finished adjuvant treatment 6 months to three years ago and report thinking or memory problems and a low MIND diet score to see if it helps compared with usual diet.
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Pembrolizumab for advanced cutaneous sarcomas (excluding angiosarcoma)
This will try pembrolizumab every three weeks in adults with advanced or metastatic skin-based sarcomas that are not angiosarcoma.
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Using HDAC inhibition to enhance immunotherapy response in bladder cancer
This study is testing a new combination treatment for patients with muscle invasive bladder cancer who can't take certain chemotherapy, to see if it helps improve their outcomes before surgery.
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CD40L-augmented tumor-infiltrating lymphocyte (TIL) therapy for advanced melanoma
This trial will test a single infusion of CD40L-augmented tumor-infiltrating lymphocytes after chemotherapy in people with advanced or metastatic melanoma who have progressed on standard treatments.
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Elranatamab treatment after cilta-cel for high-risk relapsed myeloma patients
This study is testing if Elranatamab can help high-risk myeloma patients who have already had cilta-cel live longer without their disease getting worse.
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Screening for metastasis in node-positive breast cancer after treatment
This study is testing how often breast cancer spreads to other parts of the body in patients who have had chemotherapy and surgery, by using CT scans to check for any signs of metastasis.
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Using Tafasitamab and Lenalidomide for Large B-cell Lymphoma after CAR-T Therapy
This study is testing if the combination of tafasitamab and lenalidomide can help people with Large B-cell Lymphoma who still have cancer after CAR-T therapy.
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Education and screening for colorectal cancer and hepatitis C
This study is trying to see if educating patients aged 45-75 about colorectal cancer and hepatitis C can help them get screened for these conditions more often.
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Assessing treatment outcomes of Pembrolizumab in Black patients with advanced lung cancer
This study is testing if a combination of chemotherapy and Pembrolizumab can help Black patients with advanced lung cancer who haven't been treated before.
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Using digoxin to treat relapsed medulloblastoma in young patients
This study is testing if digoxin can help young patients with relapsed medulloblastoma feel better when other treatments have not worked.
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Combining CLAG-M therapy with venetoclax for relapsed or refractory acute myeloid leukemia
This study is testing if adding a drug called venetoclax to a standard treatment for relapsed or refractory acute myeloid leukemia can help patients feel better and live longer.
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Comparing Ruxolitinib and Prednisone for treating chronic GVHD
This study is testing whether Ruxolitinib works better than Prednisone for adults with chronic graft-versus-host disease who need treatment.
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Combining ACR-368 and low dose gemcitabine for treating advanced head and neck cancer
This study is testing if combining ACR-368 with a low dose of gemcitabine can help people with advanced head and neck cancer feel better and live longer.
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Increasing enrollment of Black and Hispanic patients in cancer clinical trials
This study is trying to see if targeted outreach and support can help more Black and Hispanic patients join cancer clinical trials at Moffitt Cancer Center.
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Treatment with Enfortumab Vedotin for Advanced Colorectal and Liver Cancer
This study is testing if a new drug called enfortumab vedotin can help adults with advanced colorectal or liver cancer who haven’t had success with other treatments.
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Combination of Pirtobrutinib and Brexucabtagene Autoleucel for Relapsed Mantle Cell Lymphoma
This study is testing if combining two treatments, Pirtobrutinib and Brexucabtagene Autoleucel, can help people with relapsed mantle cell lymphoma feel better and improve their outcomes.
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Stopping chemotherapy for patients with Acute Myeloid Leukemia after successful treatment
This study is testing if adults with Acute Myeloid Leukemia who are in complete remission can safely stop their treatment after one year without the cancer coming back.
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Support program for patients with gastroesophageal cancer
This study tests if a special support program with nutrition help can improve the health of patients with gastroesophageal cancer compared to regular care during their treatment.
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Personalized vaccine for high-risk triple negative breast cancer after chemotherapy
This study is testing a personalized vaccine made from a patient's own immune cells to see if it can help people with high-risk triple negative breast cancer fight any leftover cancer after chemotherapy.
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Exercise program for patients with esophageal cancer before surgery
This study tests whether a structured exercise program can help patients with esophageal cancer get stronger and healthier before their surgery to improve their recovery.
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Exercise and nutrition program for pancreatic cancer patients
This study is testing a program that combines exercise and nutrition advice for pancreatic cancer patients to see if it helps them get healthier before surgery.
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A program to develop new treatment strategies for pediatric cancer patients with limited options
This study is testing a new program that brings together experts to find better treatment options for kids with cancer who have few choices left.
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New treatment approach for metastatic breast cancer using existing drugs
This study is testing a new way to use existing cancer drugs in a specific order to see if it can help women with hormone-positive, HER2-negative metastatic breast cancer who have already tried other treatments.
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Combining rituximab and zanubrutinib for treating indolent B-cell lymphomas
This study is testing if combining two medications, rituximab and zanubrutinib, can help people with untreated indolent B-cell lymphomas feel better and improve their treatment outcomes.
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Combining avapritinib and decitabine for treating systemic mastocytosis with associated hematologic neoplasm
This study is testing a new combination treatment of avapritinib and decitabine to see if it can help people with systemic mastocytosis and related blood cancers feel better and manage their condition more effectively.
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Using biomarkers to detect early HPV-related throat cancer
This study is testing a new way to use DNA and gene markers to see if they can help find early signs of throat cancer linked to HPV in newly diagnosed patients.
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Neoadjuvant and adjuvant immunotherapy for advanced melanoma
This study is testing if a new type of immunotherapy can help people with advanced melanoma do better before and after surgery.
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Combining Sacituzumab Govitecan and Zimberelimab with Stereotactic Radiation for Metastatic Triple Negative Breast Cancer with Brain Metastases
This study is testing if combining two treatments, Sacituzumab Govitecan and Zimberelimab, with targeted radiation can help adults with metastatic triple negative breast cancer that has spread to the brain feel better compared to just using Sacituzumab Govitecan alone.
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Using modified T cells to target prostate cancer cells
This study is testing a new treatment using modified T cells to see if it can help men with advanced prostate cancer who have run out of other options.
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Treatment for B-Cell Acute Lymphoblastic Leukemia with KTE-X19
This study is testing if a new CAR T-cell therapy called KTE-X19 can help adults with B-Cell Acute Lymphoblastic Leukemia who are in remission but still have some leftover cancer cells.
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Personalized radiation therapy for head and neck cancer
This study is testing whether using MRI to tailor radiation therapy can improve treatment for people with head and neck cancer.
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Combining Cemiplimab and Ziv-Aflibercept for Metastatic Uveal Melanoma
This study is testing if the combination of Cemiplimab and Ziv-Aflibercept can help shrink tumors or stop their growth in people with metastatic uveal melanoma who have already tried other treatments.
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Ablative radiation before CAR-T therapy for high-risk lymphoma
This study is testing if giving radiation therapy before CAR T-cell treatment can help people with high-risk lymphoma have better results.
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Tumor-infiltrating lymphocyte therapy for children and young adults with high-risk solid tumors
This will test whether doctors can grow a child’s own tumor‑infiltrating lymphocytes and safely give them back with chemotherapy and interleukin‑2 to treat high‑risk pediatric solid tumors.
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Increasing cancer awareness and education in Hispanic communities
This study is trying to see if educational programs and community forums can help Hispanic communities learn more about cancer and reduce health disparities.
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Using itacitinib to improve CAR T cell therapy outcomes in lymphoma patients
This study is testing if taking itacitinib before and after CAR T cell therapy can help improve outcomes for lymphoma patients with high inflammation levels.
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Helping Cambodian people with HIV quit smoking using text messages
This study is testing if sending text messages can help people in Cambodia who have HIV quit smoking by providing support and resources.
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Using enhanced immune cells to treat specific types of lung cancer
This study is testing a new treatment using special immune cells and a drug to see if it can help people with advanced lung cancer that has certain genetic changes and hasn’t improved with previous treatments.
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Evaluating biomarkers for diagnosing and monitoring lung cancer
This study is testing if certain blood and tissue markers can help doctors better diagnose lung cancer and identify patients at risk for recurrence after surgery.
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Comparing different dosing schedules of Vismodegib for advanced skin cancer
This study is testing different ways to take Vismodegib to see which schedule works best for adults with advanced skin cancer.
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CalPeg treatment for newly diagnosed acute lymphoblastic leukemia
This study is testing if adding a new treatment called calaspargase pegol to standard chemotherapy helps people with newly diagnosed acute lymphoblastic leukemia feel better and have fewer side effects.
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Combining CPX-351 with Gemtuzumab Ozogamicin for Newly Diagnosed AML
This study is testing a combination of two treatments, CPX-351 and gemtuzumab ozogamicin, to see if they are safe and effective for adults with newly diagnosed acute myeloid leukemia (AML).
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Genomically guided radiation therapy for triple negative breast cancer
This study is testing if personalized radiation therapy based on the genetic makeup of triple negative breast cancer can improve treatment for patients who have had breast-conserving surgery.
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Combining dostarlimab and niraparib for advanced penile cancer
This study is testing if a new combination of two drugs, dostarlimab and niraparib, can help people with advanced penile cancer who haven't had success with other treatments.
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DC1 dendritic-cell vaccine with chemotherapy for early-stage triple-negative and ER-low breast cancer
This trial will test whether a dendritic cell vaccine given with standard chemotherapy helps people with early-stage triple-negative or ER-low breast cancer.
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HER2-targeted vaccine combined with standard chemotherapy for breast cancer
This study is testing if adding a new vaccine to standard chemotherapy can help people with HER2-positive breast cancer have better treatment results.
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Infusion of modified T cells to target ovarian cancer
This study is testing a new treatment using modified immune cells to see if they can safely help people with recurring ovarian cancer.
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Using advanced radiation therapy for high-grade soft tissue sarcoma treatment
This study is testing a new way of using advanced radiation therapy to treat high-grade soft tissue sarcoma by targeting specific areas of the tumor to improve treatment while protecting healthy tissue.
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Screening brain MRIs for patients with stage IV breast cancer
This study tests if regular brain MRI scans can help find hidden issues in the brains of patients with stage IV breast cancer who don’t have any symptoms yet.
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Combining Vyxeos and Gilteritinib for FLT3-Mutated Acute Myeloid Leukemia
This study is testing if combining two drugs, vyxeos and gilteritinib, can help people with FLT3-mutated acute myeloid leukemia who have not responded to previous treatments.
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Using Cemiplimab before surgery for skin cancers
This study is testing if giving a new immunotherapy drug before surgery can help people with certain types of skin cancer have better outcomes.
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Combining Stereotactic Radiation with Abemaciclib for Breast Cancer Brain Metastases
This study is testing if combining a medication called abemaciclib with targeted radiation can help people with hormone receptor-positive breast cancer that has spread to the brain live longer without their cancer getting worse.
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Adjuvant therapy for melanoma based on treatment response
This study tests if a combination of new medications can help people with melanoma who have a specific gene mutation stay cancer-free after their initial treatment.
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Developing new treatment strategies for patients with incurable diseases
This study is testing a new team approach to see if personalized treatment plans from a special group can help patients with incurable diseases feel better and improve their care.
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Using PSMA-PET imaging to find early metastatic prostate cancer in men with high Decipher test scores
This study is testing a new type of imaging to see if it can help find early signs of recurring prostate cancer in men with high-risk test scores.
Quick answers
How many clinical trials run by H. Lee Moffitt Cancer Center and Research Institute are recruiting right now?
70, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 3 countries. The most sites are in United States (69 trials), Cambodia (1 trial), Puerto Rico (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 30, Phase 1: 15, Phase 1/2: 4, Early Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.