Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Exercise program for patients with esophageal cancer before surgery

Official title: Exercise Prehabilitation for Locoregional Esophageal Cancer: A Pilot Study

Run by H. Lee Moffitt Cancer Center and Research Institute · NCT06430346 · Data updated 2026-11-12

This study tests whether a structured exercise program can help patients with esophageal cancer get stronger and healthier before their surgery to improve their recovery.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment20 (estimated)
SponsorH. Lee Moffitt Cancer Center and Research Institute
Academic / other
Locations1 site (Tampa, Florida)
StatusRecruiting
StartedMay 21, 2024
Main results expectedMay 2027
Study endsMay 2027
Registry record updatedDecember 4, 2025
Trial IDNCT06430346 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include individuals with biopsy-proven locoregional esophageal cancer who are scheduled for neoadjuvant chemoradiation therapy followed by surgical resection.

Probably not a fit

Patients who regularly engage in resistance training or have significant underlying health issues may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines the feasibility and acceptability of an exercise prehabilitation program for patients diagnosed with locoregional esophageal cancer who are preparing for surgical resection. Participants will engage in a structured exercise regimen aimed at improving their physical fitness and overall health prior to undergoing surgery. The study will assess how well patients can adhere to the exercise program and its impact on their surgical outcomes. The approach focuses on enhancing patients' strength and endurance to potentially improve recovery times and surgical results.

Why it matters

Potential benefit: If successful, this program could enhance recovery and surgical outcomes for patients undergoing treatment for esophageal cancer.

How similar studies have gone: Previous studies have shown positive outcomes with exercise prehabilitation in various surgical populations, suggesting potential benefits in this context as well.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Biopsy-proven locoregional esophageal cancer (LEC)
* Eastern Cooperative Oncology Group (ECOG) performance status 0-2
* Treatment plan including neoadjuvant chemoradiation therapy and surgical resection
* Ability to read and speak English

Exclusion Criteria:

* Regular engagement in resistance training (2x/week targeting all major muscle groups)
* Screen failure for exercise safety based on PAR-Q
* Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease
* Recent fracture or acute musculoskeletal injury that precludes ability to participate in resistance training safely
* Numeric pain rating scale of 7 or more out of 10
* Myopathic or rheumatologic disease that impacts physical function

Where it's running

  • Moffitt Cancer Center
    Tampa, Florida, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.